The Role of TWIST in Ovarian Epithelial Cancers
김경빈, 박은영, 윤만수, 서동수, 김기형, 이정희, 신동훈, 김지연, 설미영, 최경운,
소속 상세정보
김경빈 ( Kim Kyung-Bin )
Pusan National University Yangsan Hospital Department of Pathology
박은영 ( Park Eun-Young )
Pusan National University School of Medicine Department of Pathology
윤만수 ( Yoon Man-Soo )
Pusan National University School of Medicine Department of Obstetrics and Gynecology
서동수 ( Suh Dong-Soo )
Pusan National University College of Medicine Department of Obstetrics and Gynecology
김기형 ( Kim Ki-Hyung )
Pusan National University College of Medicine Department of Obstetrics and Gynecology
이정희 ( Lee Jeong-Hee )
Pusan National University Yangsan Hospital Department of Pathology
신동훈 ( Shin Dong-Hoon )
Pusan National University Yangsan Hospital Department of Pathology
김지연 ( Kim Jee-Yeon )
Pusan National University Yangsan Hospital Department of Pathology
설미영 ( Sol Mee-Young )
Pusan National University Yangsan Hospital Department of Pathology
최경운 ( Choi Kyung-Un )
Pusan National University Yangsan Hospital Department of Pathology
KMID : 0357920140480040283
Abstract
Background: Epithelial-mesenchymal transition (EMT) is associated with tumor hypoxia. EMT is regulated, in part, by the action of TWIST, which inhibits of E-cadherin expression and may interfere with the p53 tumor-suppressor pathway.
Methods: We examined the expression of TWIST, E-cadherin, hypoxia-inducible factor 1α (HIF1α), and p53 by immunohistochemistry in 123 cases of ovarian epithelial cancers (OEC) to evaluate the role of TWIST in OEC. We assessed the association between protein expression and clinicopathologic parameters.
Results: The expression of TWIST, E-cadherin, HIF1α, and p53 proteins was found in 28.5%, 51.2%, 35.0%, and 29.3% of cases, respectively. TWIST expression was associated with higher histologic grade and unfavorable survival. TWIST expression was correlated with HIF1α expression and reduced E-cadherin expression. The altered HIF1α/TWIST/E-cadherin pathway was associated with lower overall survival (OS), while the co-expression of TWIST and p53 was correlated with lower progression-free survival. In the multivariate analyses, TWIST expression was an independent prognostic factor for OS.
Conclusions: Our data imply that TWIST expression could be a useful predictor of unfavorable prognosis for OEC. TWIST may affect the p53 tumor-suppressor pathway. Moreover, hypoxia- mediated EMT, which involves the HIF1α/TWIST/E-cadherin pathway may play an important role in the progression of OEC.
키워드
Ovarian epithelial cancer; TWIST transcription factor; Cadherins; HIF1α; Tumor suppressor protein p53
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