Histologic Disorderliness in the Arrangement of Tumor Cells as an Objective Measure of Tumor Differentiation
서성욱, 박경신, 이영섭, 정요셉, 이연수, 최영진,
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서성욱 ( Suh Sung-Wook )
Catholic University College of Medicine Department of Hospital Pathology
박경신 ( Park Gyeong-Sin )
Catholic University College of Medicine Department of Hospital Pathology
이영섭 ( Lee Young-Sub )
Catholic University College of Medicine Department of Hospital Pathology
정요셉 ( Chong Yo-Sep )
Catholic University College of Medicine Department of Hospital Pathology
이연수 ( Lee Youn-Soo )
Catholic University College of Medicine Department of Hospital Pathology
최영진 ( Choi Yeong-Jin )
Catholic University College of Medicine Department of Hospital Pathology
KMID : 0357920140480050339
Abstract
Background: Inter-observer and intra-observer variation in histologic tumor grading are well documented. To determine whether histologic disorderliness in the arrangement of tumor cells may serve as an objective criterion for grading, we tested the hypothesis the degree of disorderliness is related to the degree of tumor differentiation on which tumor grading is primarily based.
Methods: Borrowing from the statistical thermodynamic definition of entropy, we defined a novel mathematical formula to compute the relative degree of histologic disorderliness of tumor cells. We then analyzed a total of 51 photomicrographs of normal colorectal mucosa and colorectal adenocarcinoma with varying degrees of differentiation using our formula.
Results: A one-way analysis of variance followed by post hoc pairwise comparisons using Bonferroni correction indicated that the mean disorderliness score was the lowest for the normal colorectal mucosa and increased with decreasing tumor differentiation.
Conclusions: Disorderliness, a pathologic feature of malignant tumors that originate from highly organized structures is useful as an objective tumor grading proxy in the field of digital pathology.
키워드
Neoplasm grading; Colonic neoplasms; Entropy
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