Mdm2 and p53 Expression in Radiation-Induced Sarcomas of the Head and Neck: Comparison with De Novo Sarcomas
송민정, 송준선, 노종렬, 최승호, 남순열, 김상윤, 김성배, 이상욱, 조경자,
소속 상세정보
송민정 ( Song Min-Jeong )
University of Ulsan College of Medicine Asan Medical Center Department of Pathology
송준선 ( Song Joon-Seon )
University of Ulsan College of Medicine Asan Medical Center Department of Pathology
노종렬 ( Roh Jong-Lyel )
University of Ulsan College of Medicine Asan Medical Center Department of Head and Neck Surgery
최승호 ( Choi Seung-Ho )
University of Ulsan College of Medicine Asan Medical Center Department of Head and Neck Surgery
남순열 ( Nam Soon-Yuhl )
University of Ulsan College of Medicine Asan Medical Center Department of Head and Neck Surgery
김상윤 ( Kim Sang-Yoon )
University of Ulsan College of Medicine Asan Medical Center Department of Head and Neck Surgery
김성배 ( Kim Sung-Bae )
University of Ulsan College of Medicine Asan Medical Center Department of Medical Oncology
이상욱 ( Lee Sang-Wook )
University of Ulsan College of Medicine Asan Medical Center Department of Radiation Oncology
조경자 ( Cho Kyung-Ja )
University of Ulsan College of Medicine Asan Medical Center Department of Pathology
KMID : 0357920140480050346
Abstract
Background: The pathogenesis of radiation-induced sarcomas (RISs) is not well known. In RIS, TP53 mutations are frequent, but little is known about Mdm2-p53 interaction, which is a recent therapeutic target of sarcomas.
Methods: We studied the immunohistochemical expression of Mdm2 and p53 of 8 RISs. The intervals between radiation therapy and diagnosis of secondary sarcomas ranged from 3 to 17 years.
Results: Mdm2 expression was more common in de novo sarcomas than RISs (75% vs 37.5%), and p53 expression was more common in RISs than in de novo cases (75% vs 37.5%). While half of the RISs were Mdm2(?)/p53(+), none of de novo cases showed such combination; while half of de novo sarcomas were Mdm2(+)/p53(?), which are a candidate group of Mdm2 inhibitors, only 1 RIS showed such a combination. Variable immunoprofiles observed in both groups did not correlate with tumor types, except that all of 2 myxofibrosarcomas
were Mdm2(+)/p53(+).
Conclusions: In conclusion, we speculated that both radiation-induced and de novo sarcomagenesis are not due to a unique genetic mechanism. Mdm2-expression without p53 overexpression in 1 case of RIS decreases the future possibility of applying Mdm2 inhibitors on a subset of these difficult tumors.
키워드
Cancer; radiation induced; Head and neck neoplasms; Sarcoma; Mdm2 protein; human; Tumor suppressor protein p53
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