Hybrid Granular Cell Tumor/Perineurioma
김성순, 최유덕, 이제혁, 최찬, 박창수,
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김성순 ( Kim Sung-Sun )
Chonnam National University Medical School Department of Pathology
최유덕 ( Choi Yoo-Duk )
Chonnam National University Medical School Department of Pathology
이제혁 ( Lee Jae-Hyuk )
Chonnam National University Medical School Department of Pathology
최찬 ( Choi Chan )
Chonnam National University Medical School Department of Pathology
박창수 ( Park Chang-Soo )
Chonnam National University Medical School Department of Pathology
KMID : 0357920140480060409
Abstract
Hybrid peripheral nerve sheath tumors (PNSTs), which show hybrid features of more than one cell type normally found in a peripheral nerve sheath, are recently recognized clinical entities. Various composite tumors have been reported; however, granularcell tumor/perineurioma is a rare combination.1-4 Since perineurial cells may be found in other types of PNSTs, it is important to determine if those are reactive, remnantal, or true neoplastic when a perineurial component of the PNST is identified. Main differential diagnoses include granular perineurioma and granular cell tumor with reactive perineurial cell hyperplasia, which show a lack of immunopositivity for S-100 in the granular cells and prominent perineurial cell proliferation throughout the tumor, respectively.
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