Çѱ¹ ¿©¼º¿¡¼ ÁßÁõÀڱ󻸷Áõ°ú CYP1B1 À¯ÀüÀÚ ´ÙÇü¼º°úÀÇ °ü·Ã¼º¿¡ °üÇÑ ¿¬±¸
Association of the CYP1B1 Gene Polymorphism with the Risk of Advanced Endometriosis in Korean Women
Á¶¿¬Áø, Ç㼺Àº, ÀÌÁö¿µ, ¼ÛÀοÁ, ±Ã¹Ì°æ, ¹®Çý¼º, Á¤Çý¿ø,
¼Ò¼Ó »ó¼¼Á¤º¸
Á¶¿¬Áø ( Cho Yun-Jin )
¼º±Õ°ü´ëÇб³ ÀÇ°ú´ëÇÐ Á¦ÀϺ´¿ø »êºÎÀΰú
Ç㼺Àº ( Hur Sung-Eun )
°Ç¾ç´ëÇб³ ÀÇ°ú´ëÇÐ »êºÎÀΰúÇб³½Ç
ÀÌÁö¿µ ( Lee Ji-Young )
°Ç±¹´ëÇб³ ÀÇ°ú´ëÇÐ »êºÎÀΰúÇб³½Ç
¼ÛÀοÁ ( Song In-Ok )
¼º±Õ°ü´ëÇб³ ÀÇ°ú´ëÇÐ Á¦ÀϺ´¿ø »êºÎÀΰú
±Ã¹Ì°æ ( Koong Mi-Kyoung )
¼º±Õ°ü´ëÇб³ ÀÇ°ú´ëÇÐ Á¦ÀϺ´¿ø »êºÎÀΰú
¹®Çý¼º ( Moon Hye-Sung )
ÀÌÈ¿©ÀÚ´ëÇб³ ÀÇ°ú´ëÇÐ »êºÎÀΰúÇб³½Ç
Á¤Çý¿ø ( Chung Hye-Won )
ÀÌÈ¿©ÀÚ´ëÇб³ ÀÇ°ú´ëÇÐ »êºÎÀΰúÇб³½Ç
KMID : 0358220060330020085
Abstract
¸ñ Àû: CYP1B1Àº Àڱ󻸷ÁõÀÇ ¹ß»ý°ú °ü·ÃµÈ ¿¡½ºÆ®·Î°ÕÀÇ ´ë»ç ¹× dioxinÀÇ ´ë»ç ¸ðµÎ¿Í °ü·ÃÀÌ ÀÖ´Â À¯ÀüÀÚ·Î »ý°¢ÇÏ¿© Àڱ󻸷ÁõÀÇ ¹ß»ýÀ§Çè°ú CYP1B1ÀÇ codon 119G¡æT, 432G¡æC,449T¡æC, 453A¡æGÀÇ À¯ÀüÀÚ ´ÙÇü¼º°úÀÇ °ü°è¿¡ ´ëÇؼ ¾Ë¾Æº¸°íÀÚ ÇÏ¿´´Ù.
¿¬±¸¹æ¹ý: º´¸®Á¶Á÷ÇÐÀûÀ¸·Î Àڱ󻸷Áõ III±â¿Í IV±âÀÓÀ» È®ÀÎÇÑ ¿©¼º 199¸í°ú ´ëÁ¶±ºÀ¸·Î Àڱ󻸷Áõ ȯÀÚ±º°ú ¿¬·ÉÀÌ ºñ½ÁÇÑ ¿©¼º¿¡¼ ¾ç¼º ³¼Ò ³¶Á¾À¸·Î ¼ö¼úÀ» ½ÃÇàÇÏ¿© Àڱ󻸷ÁõÀÌ ¾øÀ½À» À°¾ÈÀ¸·Î È®ÀÎÇÑ 183¸íÀ» ´ë»óÀ¸·Î PCR ¹× RFLP¸¦ ½ÃÇàÇÏ¿© CYP1B1ÀÇ codon 119G¡æT, 432C¡æG, 449T¡æC, 453A¡æGÀÇ ´ÙÇü¼ºÀ» Á¶»çÇÏ¿´´Ù.
°á °ú: CYP1B1¿¡¼ Ala119Ser, Val432Leu, Asn449 (T449¡æC), Asn453Ser °¢°¢ÀÇ À¯ÀüÀÚ ´ÙÇü¼ºÀº ±× ºÐÆ÷¿Í À§Çèµµ¿¡ ÀÖ¾î¼ Àڱ󻸷Áõ ȯÀÚ¿Í ´ëÁ¶±º °£¿¡ Åë°èÀûÀ¸·Î À¯ÀÇÇÑ Â÷ÀÌ´Â ¾ø¾ú´Ù. CYP1B1¿¡¼ ¾Õ¼ ¹àÈù 4°¡Áö codonÀÇ ´ÙÇü¼ºÀ» Á¶ÇÕÇÑ °á°ú GG/CC/CC/AAÀÇ À¯ÀüÀÚÇüÀ» °®´Â ¿©¼º¿¡ ºñÇØ GG/GC+GG/TC+TT/AAÀÇ À¯ÀüÀÚÇüÀ» °®´Â °æ¿ì¸¸ÀÌ Àڱ󻸷ÁõÀÇ À§Çèµµ°¡ 2.056 (95% CI: 1.003~4.216)À¸·Î À¯ÀÇÇÏ°Ô ³ôÀº °ÍÀ» ¾Ë ¼ö ÀÖ¾ú´Ù.
°á ·Ð: ÀÌ»óÀ¸·Î º¼ ¶§ Çѱ¹ÀÎ ¿©¼º¿¡¼ ÁßÁõÀڱ󻸷Áõ ¹ß»ýÀº CYP1B1ÀÇ À¯ÀüÀû ´ÙÇü¼º°ú °ü·ÃÀÌ ÀÖ´Â °ÍÀ¸·Î º¸À̸ç, ÇâÈÄ Àڱ󻸷ÁõÀÇ ¹ß»ý ±âÀüÀ» ¹àÈ÷´Âµ¥ ÁÖ¿äÇÑ ÀÚ·á°¡ µÉ °ÍÀ¸·Î º»´Ù.
Objective: To investigate whether polymorphisms of gene encoding CYP1B1 is associated with the risk of endometriosis in Korean women.
Methods: We investigated 199 patients with histopathologically confirmed endometriosis rAFS stage III/IV and 183 control group women who were surgically proven to have no endometriosis. The genetic distribution of four different CYP1B1 polymorphisms at G119-T, G432-C, T449-C, and A453-G were analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism of PCR products.
Results: We found no overall association between each individual CYP1B1 genotype and the risk of endometriosis. The odds ratio of genotype GG/GC+GG/TC+TT/AA compared to GG/CC/CC/AA (reference) was calculated as 2.06 with a 95% confidence interval of 1.003~4.216.
Conclusions: This results suggest that CYP1B1 genetic polymorphism may be associated with development of endometriosis in Korean women.
Å°¿öµå
Àڱ󻸷Áõ;CYP1B1;À¯ÀüÀÚ ´ÙÇü¼º
Endometriosis;CYP1B1;Genetic polymorphism
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