간손상이 생식선에 미치는 영향. 제3편:간손상이 웅거세백서 생식선에 대한 성Hormone 투여효과에 미치는 영향
Influence of Hepatic Damage on the Male Reproductive Glands : III. Influence of Hepatic Damage on the Effect of Exogenous Sex Hormones on the Reproductive Glands of White Castrated Rats
소속 상세정보
김영균/Kim YK
이학송/Lee HS
KMID : 0358319600010020105
Abstract
Young adult male white rats were castrated to remove the main source of production of sex hormones in the body. Carbon tetrachloride was injected to induce damage to the liver in two groups of animals. The effect of hepatic damage on the histological and biological activity of exogenous sex hormones on the accessory glands of reproduction was observed. Castration causes a very remarkable decrease in the weight of the accessory glands of reproduction. Exogenous androgen restored the glands to normal. Hepatic damage did not lay a role in the inactivation of exogenous androgen. A direct antagonism between the exogenous androgen and the exogenous estrogen seemed to be present and the hepatic damage did not play role to accelerate or suppress this action. Citric acid concentration in the prostatic tissue showed a sharp rise following castration but restoration of the gland by giving exogenous sex hormones returned the citric acid concentration to hormonal levels. The hepatic damage did not cause a rise in the citric and content when both androgens and estrogens were together. The concentration of the prostatic citrate can not be taken as an index of androgenic activity.
키워드
간손상; 내분비학; 성호르몬; liver cirrhosis; castration; male reproductive gla
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