여성 Hormone이 백서전립선성장에 미치는 영향
Effect of Estrogen on the Prostatic Gland of Adult Male White Rats
소속 상세정보
김영균/Kim YK
이학송/Lee HS
KMID : 0358319600010020129
Abstract
Estrogenic hormone in various doses and durations was administered to adult male white rats to study the hormonal effect on the prostatic gland. In this study 48 rats. weighing approximately 250 gm. were divided into 8 groups of six rats.
Group 1: Control for 2 weeks experiment
Group 2: Control for 4 weeks experiment
Group 3. Administration of estradiol 0.5 mg., 7 doses
Group 4: Administration of estradiol 0.5 mg., 14 doses
Group 5. Administration of estradiol 0. 25 mg., 7 doses
Group 6: Administration of estradiol 0. 25 mg., 14 doses
Group 7: Administration of estradiol 0. 125 mg., 7 doses
Group 8: Administration of estradiol 0. 125 mg., 14 doses
Estradiol was administered every other Day as scheduled. One day after the final injection, the animals were sacrificed. Body weight and weight of the prostatic gland, both the ventral and the dorsal lobes, were obtained. The effect of estradiol in various doses on the prostatic size was observed to be almost the same throughout the experimental groups. But estradiol administered for longer periods has slightly more effect than when administered for shorter periods. The effect of estrogen administered to the rats with intact gonads did not antagonize or neutralize the endogenous testicular androgen, but did suppress the release of pituitary gonadotrophin, resulting in less production of testicular androgen. A large dosage of estrogen does not necessarily cause a marked reduction in the prostatic weight.
키워드
내분비학; 성호르몬; 에스트로젠; 전립선; prostate; estrogen; rat
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