급성 및 만성일산화중독이 백서생식선에 미치는 영향에 관한 생화학적 연구* : 1.고환조직내 Lactate Dehydrogenase활성도
Influence of Acute and Chronic Carbon Monoxide Poisoning on Reproductive Organs of the White Rat: Enzymological Study 1. Lactate Dehydrogenase Activity in the Testis
소속 상세정보
홍태의/Hong TU
김영균/Kim YK
KMID : 0358319750160010001
Abstract
Influence of acute and chronic carbon monoxide poisoning on the rat testis has been studied enzymologically and the following results were obtained: Experimental animals were divided as 1) control, C1 (6 animals) 2) acute poisoning with 0.5% carbon monoxide until death, C2 (10 animals) 3) chronic poisoning with 0.05% carbon monoxide for 2 hours daily E1 (5 animals)...3 days/week for 8 weeks E2 (6 animals)...3 days/week for 4 weeks 4) acute poisoning until death with 0.5% carbon monoxide after chronic poisoning with 0.05% carbon monoxide E3 (5 animals)...chronic poisoning for 8 weeks plus acute poisoning E4 (5 animals)...chronic poisoning for 4 weeks plus acute poisoningUsing Neiland`s method, the total activities and distribution patterns of lactic dehydrogenase in rat testis were measured. All of the data were analyzed statistically. 1. The total activities of lactic acid dehydrogenase in all experimental groups seemed to increase. In the group E3, the increase was statistically significant.(p<0.05) 2. No significant changes were observed in the lactic acid dehydrogenase isoenzyme distribution pattern of the testis. both is the control and experimental groups. 3. The lactic acid dehydrogenase distribution patterns were as fraction l>2>4>3>5 4. No significant histopathological changes were observed in the rat testis.
키워드
고환; 독성인자; testis; carbon monoxide; LDH; poisoning
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