남자불임환자의 Sertoli세포의 세포내 소기관의 형태적 변화
On Changes of fine Structures of the Sertoli Cells in the Human Male Sterility
소속 상세정보
조성용/Cho SR
KMID : 0358319750160020081
Abstract
Electron microscopic observation of fine structural changes of Sertoli cells in the male sterility patients was made on 10 histologically proved cases. They were histologically classified to 3 groups by Nelson`s classification, hypospermatogenesis, spermatogenic arrest and germinal cell aplasia. The results obtained were summarized as follows. l) The findings of ultrastructures of Sertoli cells in the normal man showed no significant differences with other author`s results. 2) The ultrastructures of Sertoli cells in the male sterility revealed degenerative changes, characterized by fragmentation and dilatation of subsurface cisternae, swelling and vacuolization of mitochondria with decrease in the number of cristae and poor development of Golgi apparatus. And also observed were proliferative changes, characterized by increase in the number of sER, rER and ribosome. These morphological changes were severer in spermatogenic arrest and the severest in germinal cell aplasia. 3) The results were suggested that the most significant ultrastructural changes of Sertoli cells of male sterility were the degenerative changes of the organelles of protein synthesis and protein transport system such as rER, ribosome and Golgi apparatus.
키워드
불임증; 남성; Sertoli cell; sterility
원문 및 링크아웃 정보
등재저널 정보