Papaverine HCL의 산성도가 가토 음경해면체의 섬유화에 미치는 영향에 대한 실험적 연구
An Experimental Study on the Effect of Acidity of Papaverine hCl on Fibrosis of the Corpus Cavernosum of Rabbit
김영찬, 최형기, 안영수, 김경환,
소속 상세정보
김영찬 ( )
영남대학교
최형기 ( )
영남대학교
안영수 ( )
영남대학교
김경환 ( )
영남대학교
KMID : 0358319920330020325
Abstract
This study was designed to investigate whether fibrosis of the corpus cavrnuoum(CC) induced by repeated intracavernous injection of papaverine HCI was related to pH of the drug. Forty-eight New Zealand White rabbits weighing 2.5kg-3.0kg were
divided
into 4 groups of 12 animals each. Group I received isotonic saline, Group 2;p pH 2,0 papaverine HCI, Group 3; pH 3.0 papaverine HCI and Group 4; pH 4.0 papaverine HCI. The solution (0.1ml isotonic saline or 2mg. papaverine HCI of each pH) was
injected
intracorporeally twice every week for 6 months. Every one month since beginning of the injection, 2 animals of each group were sacrified, the penis was observed with H & E and Masson's trichorome stain microscopically.No sign of fibrosis was
found
in
the CC of the group 1 even after 6months of injection. However, Group 2, 3 and 4 began to show focal of diffuse thin fibrotic changes after 2 months of injection. The fibrotic changes progressed more and more in accordance with the frequency of
papaverine HCI injection. After 4 months of injection. Group 2 showed diffuse thick fibrosis whereas Group 3 and 4 shoed diffuse thin or focal thick fibrosis. In conclusion, intracavernous papaverine itself seems to play a main role to induce
fibrosis
of CC. However, the acidity of the papaverine HCI also might be responsible to development of the fibrosis when injected repeatedly for a long period.
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