경구 Oxybutynin Chloride에 효과가 없었던 척수손상 환자에서 방광내 투여의 효과
The Effects of Intravesical Oxybutynin Chloride in Spinal cord Injury Patients Who Had Clinical Problems on Oral Medication
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KMID : 0358319950360030306
Abstract
Oxybutynin chloride was administered intravesically in 7 spinal cord injury patients with persistent incontinence and freqeunt side effects on oral medication. Five mg tablets were dissolved in 20 ml normal saline, and the solution was instilled
twice
daily and retained for 30 minutes. All patients reported subjective improvement following tratment and all became totally continent. No side effects were observed. In urodynamic study mean bladder capacity increased from 250 to 400 ml(P=0.005)
and
mean
maximum filling pressure decreased from 25 to 18cmH2O (P=0.283).
In conclusion treatment with intravesical oxybutynin chloride can be effective in spinal cord injury patients who either are unresponsive to or have intolerable side effects on oral medication.
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