고환염전의 정복후 발생되는 재관류손상에 대한 Free Radical Scavenger의 효과
The Effect of Free Radical Scavengers on Reperfusion Injury after Testicular Torsion.
이서학, 박경준, 최창진,
소속 상세정보
이서학 ( )
가톨릭대학교
박경준 ( )
가톨릭대학교
최창진 ( )
가톨릭대학교
KMID : 0358319960370020121
Abstract
The free radicals generated during the ischemic/reperfusion period have been suggested as a possible cause for tissue damage in organs. This state was conducted to investigate protective effects of free radical scavengers through changes in the
lipid
peroxide content of the testis when administered before reperfusion of testicular torsion. These protective agents include superoxide dismutase(SOD), an oxygen radical scavenger and dimetinylthiourea9DMTU), a hydroxyl radical scavenger.
Forty five Sprague-Dawley rats were divided into 9 groups, each containing 5 rats. Group 1 served to determine basal values of the lipid peroxide content of the testis ; group 2 underwent sham operation as a control ; group 3 was subjected to
unilateral
testicular torsion lasting 3 hours; group 4, 5 were subjected to the detorsion lasting 1 hour and 2 hours following torsion for 3 hours; group 6, 7, 8, 9 were treated with SOD or DMTU before detorsion following torsion lasting 3 hours.
The measurement of thiobarbituric acid reactive products of lipid peroxidation9TBAR0 wer employed to assess the extent of lipid peroxidation in testicular tissues. TBAR from sham operation control groups didd not differ significantly from basal
groups
(p>0.05). Testicular torsion caused a significant increase in TBAR in the testis (p<0.05) when compares with basal values and detorsion caused a further significant increase when compared with values obtained after torsion. But TBAR after 1 hr
detorsion
did not change significantly compared with values obtained after 2 hours detorsion. The pretreatment with SOD prevented this further increase but the pretreatment with DMTU didn't
In conclusion, biochemically, reperfusion injury occurs in testis following detorsion after testicular torsion 720* lasting 3 hours. The pretreatment with SOD, and oxygen radical scavenger, is effective in preventing reperfusion injury.
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