방광 흰쥐 음경해면체의 전장자극에 대한 이완반응
Prognostic Significance of Bcl-2 Expression in Transitional Cell Carcinoma of the Bladdder
신기용, 공구, 문홍상, 김선진, 이춘용, 이중달, 우영남,
소속 상세정보
신기용 ( )
한양대학교
공구 ( )
한양대학교
문홍상 ( )
한양대학교
김선진 ( )
한양대학교
이춘용 ( )
한양대학교
이중달 ( )
한양대학교
우영남 ( )
한양대학교
KMID : 0358319960370101080
Abstract
The protein encoded by the Bcl-2 proto-oncogene has been shown to prolong cell survival by preventing programmed cell death (apoptosis). Recent work has elucidated Bcl-2 expression in many solid tumors including bladder tumor. Because there
exists
some
controversy as to the prognostic significance of Bcl-2 in bladder cancer, we examined the cellular expression of Bcl-2 protein using immunohistochimistry in tumor samples from 89 patients with bladder cancer and determined whether expression of
Bcl-2
has prognostic significance in cancer. We found positive staining for Bcl0-2 (>5% positive cells) in 41 patients (40%). Bcl-2 expression was strongly correlated with tumor stage and grade (superficial vs. invasive, p<0.025; grade II vs. grade
III&IV,
p<0.005). In superficial tumors, Bcl-2 expression was not correlated with diseasefree survival (>0.1) and weakly correlated with progression-free survival (p<0.1). In invasive tumors, Bcl-2 expression was correlated with shortened actuarial
survival
(p<0.025). We assessed the edffect of Bdcl-2 status on the response to chemotherapy or radiotherapy in 25 patients with invasive tumor. The patients with Bcl-2 positive tumors had significantly higher response rate than with Bcl-2 negative tumors
(p<0.05). These results suggest that Bcl-2 protein plays an important role in tumorigenesis of bladder cancer and that Bcl-2 expression is not superior to tumor stage and grade in assessing the prognosis of patients with superficial tumors.
However,
Bcl-2 expression is associated with shortened actuarial survival in the patients with invasive tumor, which may be partly due to chemosensitivity or radiosensitivity in relation to the apoptotic process.
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