소아 야뇨증치료에서 Desmopressin의 비강내 투여 효과
The Efficacy of intranasal Desmopressin in the Treatment of Nocturnal Enuresis
김왈범, 강대주,
소속 상세정보
김왈범 ( )
중앙대학교
강대주 ( )
중앙대학교
KMID : 0358319970380050523
Abstract
The treatment of choice for primary nocturnal enuresus(PNE) in Korea remains imipramine which has proven to be effective in approximately 50 to 80%, but it is an antidepressant with toxic side effects and risk of overdose. Recently desmopressin
(DDAVP,
1-desamino-8-D-arginine-vasopressin) has been introduced for the treatment and its effect has been promising in many reports.
To find the efficacy and safety of intranasal desmopressin, we evaluated the results of therapy in 48 enuretic children (34 boys and 14 girls). Mean age was 9.8 years(range 5-16). All the children were evaluated at least 3 months after the
treatment
with intranasal desmopressin.
The overall response rate was 83.3%. The number of wet night per week before and after intranasal desmopressin treatmint was 6.42 and 1.83 nights per week respectively. No side effects were observed.
These data shows that the intranasal desmopressin therapy is effective and safe for the treatment of PNE.
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