수산칼슘 결정화에 미치는 Magnesium Oxide와 Sodium Thiosulfate의 효과
Effectiveness of Magnesium Oxide and Sodium Thiosulfate in Calcium Oxalate Crystallization
소속 상세정보
문영태/Young Tae Moon
방장호/김태형/안승용/김미경/Chang Ho Bang/Tae Hyoung Kim/Seung Yong Ahn/Mi Kyung Kim
KMID : 0358319970380070695
Abstract
결론
체중 200 gm내외의 암수 Wistar 백서 48마리를 이용하여 Ethylene glycol을 투여한 실험
군과 추가로 Magnesium oxide 또는 Sodium thiosulfate를 결합하여 투여한 대조군에서의
방광천자 후 요중 수산결정체를 검사하고, 신장의 신세뇨관에서의 수산칼슘 결정체의 변화
를 조직검사로 확인하여 두군간의 결석발생의 차이를 비교분석하여 다음의 결과를 얻었다.
요중 수산결정체를 확인한 바 Magnesium oxide와 Sodium thiosulfate가 결석의 발생을
감소시킴을 확인할 수 있었고 Sodium thiosulfate의 효과보다는 Magnesium oxide의 효과가
탁월하였다. 또한 백서 신장조직에서 결정체를 정량화하여 조사한 바 실험군과 비교시
Magnesium oxide 대조군에서는 p=0.0001, Sodium thiosulfate 대조군시 p=0.0003으로 통계
적으로 의의가 있음을 수 있었다
이상의 결과는 Magnesium oxide와 Sodium hiosulfate가 수산칼슘석 성장의 억제효과가
있으며 아울러 재발을 방지하는 예방적 치료제로서 가치가 있음을 시사하며 향후 상기약제
의 인체에서의 효과, 투여방법, 적정용량이나 부작용등의 검증이 필요하리라 생각된다.
#초록#
We investigated the comparative effect of magnesium and thiosulfate on the calcium
oxalate crystallization. Magnesium is a strong inhibitor of calcium oxalate crystallization
and it is sported to inhibit calcium phophate by about 20%. Even if it's mechanism is
not clearly known, thiosulfat can resolve 250∼100,000 times more than other calcium
salts when it is combined with calcium.
Wistar rats were fed by 1.0% ethylene glycol (EG) mixed with water. 500mg of
magnesium oxide (MgO) per 100gm chows and 10mMo1 of
S2O3 per 100gm chows were provided by oral intake
respectively. Forty eight wistar rats were divided into following 6 groups. Each group
has equal 8 wistar rats; A group (normal chow and water), B group (normal chow and
1%EG), C group (MgO and 1%EG), D group (MgO and water), E group
(S2O3 and 1%EG), and F group
(S2O3 and water).
First, we examined calcium oxalate crystallization on bladder aspiration urine for 6
groups before the experiment and every week for 4 weeks after the experiment. Second,
we also examined the degree of formation of calcium oxalate crystallization in renal
tissue under polarizing microscope.
Calcium oxalate crystallization was found in all 8 wistar rats in B group while it was
not round in A, D, F group. Calcium oxalate crystallization was also found in one out of
8 wistar rats in C group, and 5 out of 8 wistar rats in E group.
In conclusion, we believe that both MgO and sodium thiosulfate are effective in
preventing calcium oxalate stone, and we also believe MgO is more elective than sodium
thiosulfate. We think that further researches on administrating methods, the side effects
and dosage of these two agents in human are necessary.
키워드
Nephrolithiasis; Magnesium oxide; Sodium thiosulfate; Prevention;
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