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Abstract

°á·Ð
Á¤»ó Çѱ¹ ³²¼ºÀÇ ÃÑ PSA¿¡ ´ëÇÑ À¯¸®Çü PSA ºñÀ²ÀÇ Æò±Õ°ªÀº 0.31¡¾0.14 ng/§¢ÀÌ°í, ¿¬
·Éº° Â÷ÀÌ´Â ¾øÀ¸¸ç, ÃÑ PSA ¹× À¯¸®Çü PSA°ªÀº ÃÑ PSA°¡ ¿¬·ÉÁõ°¡¿¡ µû¶ó Áõ°¡ÇÔ¿¡ µû
¶ó À¯¸®Çü PSAµµ Áõ°¡ÇÏ¿© ÃÑ PSA¿¡ ´ëÇÑ À¯¸®Çü PSAÀÇ ºñÀ²Àº ¿¬·Éº° Â÷ÀÌ°¡ ¾ø¾ú´Ù.
ÀÌ´Â ÃÑ PSA¸¸À¸·Î Àü¸³¼±ÁúȯÀÇ °¨º°Áø´ÜÀÌ ¾î·Á¿î °æ¿ì¿¡ ÀÓ»óÀûÀ¸·Î µµ¿òÀ» ÁÙ ¼ö ÀÖ
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Prostate specific antigen (PSA) is known as the most sensitive marker for detecting
prostate carcinoma (CaP). Nevertheless, PSA testing lacks sufficient sensitivity and
specificity to be considered the perfect tumor marker for the detection of early prostate
cancer. PSA exists in the serum in several molecular forms; free PSA and complexed
PSA (PSA complexed to ¥á-1-antichymotrypsin or a-2-macrogloburin or inter-¥á
-trypsin inhibitor). It has been suggested that analysis of level of free to total PSA
ratio improves specificily of PSA assays in the early detection of prostate carcinoma.
We measured free PSA and total PSA of 367 healthy men aged from 30 to 79 years
old using radioimmunoassay (PSA-RIACT and FPSA-RIACT kit) in order to know the
normal range of PSA, free PSA and free PSA to total PSA ratio.
The mean free to total PSA ratio in normal Korean men is 0.31¡¾0.14 and there is no
correlation with patient age.

Å°¿öµå

Prostate specific antigen; Prosate carcinoma; Free PSA; Total PSA;

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KCI
KoreaMed
KAMS