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ô¼ö¼Õ»óÀ¸·Î ÀÎÇÑ ½Å°æÀμº¹æ±¤ ȯÀÚ¿¡¼­ DesmopressinÀÇ È¿°ú The Effect of Desmopressin in Neurogenic Bladder due to Spinal Cord in Jury

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Abstract

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Purpose: Nocturia and enuresis are common voiding problems in spinal cord injured
patients despite a variety of management. The purpose of this study is to determine the
efficacy of desmopressin, a synthetic analogue of antidiuretic mono, as an alternative
treatment in the management of spinal cord injured(SCI) patients with neurogenic
bladder dysfunction unresponsive to conventional therapy.
Materials and Methods: Fourteen SCI patients with nocturia or enuresis were included
in this study. The patients received 10§¶ desmopressin intranasally at bedtime once
every 24 hours.
Results: There was a significant decrease in nocturnal urinary volume, frequency of
nocturia and nocturnal enuresis during nighttime after desmopressin administration. Two
patients stopped desmopressin because of side effects. 8 of 12 patients improved with
desmopressin and the remainder had no effect. There was no serum abnormality,
although there were side effects in three cases, such as gastro-intestinal trouble, chest
discomfort or nasal congestion.
Conclusions: Desmopressin is safe and effective in the management of nocturia or
enuresis due to neurogenic bladder dysfunction in selected SCI patients.

Å°¿öµå

Desmopressin; Spinal cord injury; Neurogenic bladder;

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