신세포암에서 p53 유전자의 변이
Mutations of p53 gene and Its Significance for Renal Cell Carcinoma
소속 상세정보
오세권/Sei Kwon Oh
최한용/김대식/이성원/박관현/이규성/채수응/Han Yong Choi/Dae Sik Kim/Sung Won Lee/Kwan Hyun park/Kyu Sung Lee/Soo Eung Chai
KMID : 0358319980390030236
Abstract
결론
48례의 신세포암에 대한 PCR-SSCP와 면역조직화학염색 분석에서 4례(8.3%. Grade III 2
례, Grade IV 2례)에서 변이를 보였고 이들은 모두 유세포검사에서 aneuploidy를 보였다 신
세포암에서 p53유전자의 역할은 뚜렷하게 밝혀져 있지 않지만 암의 진행과 악성변형에 중
요한 역할을 할 것으로 추측되며, 신세포암의 예후를 결정하는 중요한 인자가 될 수 있으리
라 생각된다. 추후 더욱 많은 증례를 대상으로 보다 광범위한 연구가 뒤따라야 할 것이다.
#초록#
Purpose: Mutation of the p53 gene seem to be the most common genetic changes in
human malignancies. Recent studies have also shown p53 gene mutations in several
premalignant conditions and preliminary data have suggested that p53 gene mutations
may be involved in tumor progression. There is wide variation in reported incidence of
p53 gene mutation in renal cell carcinoma, and its prognostic significance for this tumor
is unknown.
Materials and Methods: This retrospective PCR-SSCP(the polymerase chain reaction of
the single-strand conformation polymorphism) analysis and immunohistochemical study
were designed to investigate the role of p53 gene mutation in renal cell carcinoma and
to examine association between p53 gene mutation and tumor grade, clinical behavior
and DNA ploidy.
Results: Forty eight renal cell carcinoma(RCC) specimens were analyzed. Mutations of
p53 gene were detected in 8.3%(4/48) of tumors. There were significant correlation
between the presence of the mutation of p53 gene and high tumor grade and DNA
aneuploidy(p-value=0.016. 0.019). But no significant correlation between the presence of
the mutations of p53 gene and sex, symptom and tumor stage.
Conclusions: These results suggest that the mutations of p53 gene may not be
significant in development of RCC but may be related to its progression or malignant
transformation.
키워드
Renal cell carcinoma; p53 gene;
원문 및 링크아웃 정보
등재저널 정보