정읍지역에서의 전립선비대증 유병율의 역학조사
Prevalence of Benign Prostatic Hyperplasia in Jeong-Eup Area: Community-based Study
정태규, 정진수, 이상열, 안한종,
소속 상세정보
정태규 ( )
울산대학교 의과대학 비뇨기과학교실
정진수 ( )
울산대학교 의과대학 비뇨기과학교실
이상열 ( )
울산대학교 의과대학 예방의학교실
안한종 ( )
울산대학교 의과대학 예방의학교실
KMID : 0358319990400010052
Abstract
결론
본 연구에서는 우리 나라에서의 전립선비대증의 유병율을 추정하기 위하여 전라북도 정읍
지역에서 전립선증상지수를 이용한 설문조사와 직장수지검사, 요속검사를 시행하였다. 전립
선증상지수의 각 증상 중 야간뇨와 세뇨가 가장 흔한 증상이었으며 조사대상의 49.5%에서
중간 이상의 전립선증상을 보였고, 전국인구에서의 표준화유병율은 44.7%로 이는 다른 연구
의 결과와 유사하였다. 전립선비대증의 임상적 지표로 사용되는 전립선증상이나 전립선크기
그리고 최고요속은 서로 상관관계가 없어 어느 한가지 지표로서 임상적 의의를 갖는 전립선
비대증의 유병율을 추정하기는 어려울 것으로 생각된다. 중등도 이상의 전립선증상을 가지
며 전립선의 비대와 함께 요속의 감소를 보이는 임상적 전립선비대증은 50세 이상 남자의
11.1%였다(8.7-13.5%, 95%신뢰구간). 이 결과로 한국에서의 전립선비대증의 유병율은 백인
에 비하여 낮으며, 한국의 50세 이상 남자 중 1995년도 인구를 기준으로 약 160만명(44%)이
중등도 이상의 전립선증상을 가지고있고, 이들 중 약 30만명(8.7%)이 요속의 감소와 함께
전립선 크기가 커져 있는 임상적 의의를 갖는 전립선비대증일 것으로 추정된다.
Purpose: There is no consensus about a definition of benign prostatic hyperplasia, but
there are various definitions based on a combination of clinical parameters used to
describe the properties of BPH: symptoms of prostatism, increase of prostate volume,
and bladder outlet obstruction. The prevalence of clinical BPH in Asian was believed to
be lower than Caucasian. The lower urinary tract symptoms associated with BPH in
Korea was reported by some authors and it was similar to the results of other studies
in western countries. We report the prevalence of BPH in Korean men through a
community-based study in Jeong-Eup county, Korea.
Materials and Methods: A total of 653 men aged 50 and over in Jeong-Eup area,
Korea was randomly selected for determination of the prevalence of BPH. The definition
of BPH in this study was combination of moderate(8-19) to severe(>19) Ⅰ-PSS,
enlargement of the prostate over 30gms on digital rectal examination by one board
certified urologist, and decreased peak flow rate below 15㎖/sec. Men with abnormal
digital rectal examination(DRE) and elevated serum prostate specific antigen(PSA) above
3.5ng/㎖ were undergone sextant prostate biopsy to exclude the prostate cancer.
Results: Ⅰ-PSS questionnaires were completed in 431 men and the response rate was
66.1%. Based on Ⅰ-PSS, 162 men(37.6%) had moderate symptoms and 51 men(11.9%)
severe symptoms. Of 213 men with moderate to severe symptoms, 35.7% had enlarged
prostate by DRE, and 63.1% decreased flow rate. The prevalence of BPH by the
definition in this study was 4.3% in their fifties, 13.2% in sixties and 16.3% in seventies
and over eighty(overall, 11.1%). The population-adjusted prevalence of BPH in Korean
men aged 50 and over was 8.7%. A good correlation was found between the total
symptom score and the quality of life score that is included in the Ⅰ-PSS.
Conclusions: Men with moderate to severe Ⅰ-PSS was 49.5%, which was similar to
the results from other studies in Caucasian and Japanese. The prevalence of BPH in
Korea by aforementioned definition was 8.7%, which seems to be lower than Caucasian.
This results suggest that approximately 1,600,000 Korean men had moderate to severe
urinary symptoms and 300,000 clinical BPH by the definition in this study.
키워드
Benign prostatic hyperplasia; Prevalence; Voiding symptoms;
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