국소성 신세포암 환자에서 예후인자로서 p53단백 면역화학염색의 의의
Prognostic Implication of p53 Immunohistochemical Staining In Patients with Localized Renal Cell Carcinoma after Radical Nephrectomy
소속 상세정보
이선주/Sun Ju Lee
김덕교/이충현/장성구/김진일/김윤화/Duk Kyo Kim/Choong Hyun Lee/Sung Goo Chang/Jin Il Kim/Youn Wha Kim
KMID : 0358319990400030297
Abstract
결론
'신세포암 환자에서 p53단백 면역화학염색이 예후인자로서의 역할을 할 것인가'에 대한
연구 결과 근치적 신적출술을 시행한 국소성신세포암 환자에서 T병기 (p=0.001), p53단백
면역화학염색(p=0.005), 핵등급(p=0.027)이 예후에 영향을 미치는 인자였다. 다변량분석결과
예후에 독립적인 영향을 미치는 인자로 가장 중요한 것은 T병기(relative risk=2.19,
p=0.007)이고, 두 번째는 p53단백 면역화학염색(relative risk=1.82, p=0.017)임을 발견하였다.
이러한 결과는 국소성 신세포암 환자에서 근치적신 적출술 후 p53단백 면역화학염색이
독립예후인자로서의 충분한 역할을 하는 것으로 생각된다.
Purpose : p53 gene is a well-known suppressor gene of tumor. And the p53 protein
expression in immunohistochemical staining acts a role as a prognostic indicator in
prostate and bladder tumor. However, the validity of p53 protein expression was not
determined as an independent factor of prognosis in renal cell carcinoma(RCC).
Furthermore, there were not enough studies about whether the expression of p53 protein
plays a role as a prognostic indicator in RCC or not. Therefore, we evaluate the
prognostic significance of p53 protein expression in RCC.
Materials and Methods : To evaluate the prognostic significance of p53
immunohistochemical staining in RCC, paraffin embedded specimens taken from 84
patients with RCC were studied from January 1982 to April 1997, retrospectively. In
addition to the prognostic significance of p53 immunohistochemical staining, correlation
between p53 immunohistochemical staining and pT category, nuclear grade, and
histologic type was studied.
Results : The expression rate of p53 protein was 19.0%(16/84). The most important
prognostic indicator of RCC was pT category(relative risk=2.19, p=0.007). And the
second important prognostic indicator was the expression of p53 protein(relative
risk=1.82, p=0.017). Nuclear grade had prognostic significance(p=0.027) but was not an
independent prognostic indicator. The expression of p53 protein did not correlate with
pT category, nuclear grade or histologic pattern.
Conclusions : We have shown that the expression of p53 protein in RCC is the
second most important prognostic indicator. In conclusion, p53 immunohistochemical
staining can be used to predict the prognosis in patients with localized RCC after radical
nephrectomy.
키워드
Renal cell carcinoma; p53; Immunohistochmistry; Prognostic indicator;
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