전립선암에서 bel-2와 bax단백 발현의 의의
bcl-2 and bax Expression in Prostate Carcinoma
소속 상세정보
송영준/Young Jun Song
양대열/이성호/남은숙/김성용/김하영/박흥원/Dae Yul Yang/Sung Ho Lee/Eun Sook Nam/Sung Yong Kim/Ha Young Kim/Heung Won Park
KMID : 0358319990400060709
Abstract
서론
세포고사는 자연적 또는 병리적 상황에서 일어나는 통제된 세포사망 경로이며 이 경로에
이상이 생기면 통제되지 않는 세포증식을 일으켜 결국 종양 발생을 일으킨다. 이 과정에 관
계되는 유전자들의 돌연변이나 비정상적인 표현은 암 발생과 중요한 연관이 있으며 bcl-2단
백군들은 c-myc, p53과 더불어 대표적인 세포고사 조절자로 알려져 있다. 최근 여러 종류의
bcl-2단백군들이 밝혀지고 각종 질환에서의 발현 양상에 대한 연구가 활발히 진행되고 있으
며 전립선암에서도 발생과정, 전이성 진행과 호르몬 비의존성 상태의 획득에 중요한 역할을
하는 것으로 추정되고 있다. 따라서 저자들은 각각 대표적인 세포고사 억제자인 bel-2와
유도자인 bax단백의 전립선암에서의 표현 양상을 관찰하고 분화도, 병기, 혈청 전립선특이
항원 등과 비교 관찰을 통하여 전립선암에서의 의의를 알아보고자 하였다.
Purpose: Proteins encoded by bcl-2 family as regulators of apoptosis appear to have
significant cellular effects such that when abnormally expressed, they may render certain
cells more susceptible to aberrant proliferation. The ratio of anti-apoptotic to
pro-apoptotic bel-2 family proteins appears to control the relative sensitivity or
resistance of cells to apoptotic stimuli. The primary goal of this study is to determine
the expression pattern of bcl-2 and lax in prostate carcinoma and to correlate them with
Gleason score, T stage, and PSA to determine their prognostic potential.
Materials and Methods: We examined the cellular expression of bel-2 and lax proteins
using Immunohistochemical method in a total 35 patients with untreated prostatic
carcinoma. All tissues were scored for overall tissue expression as follows: bcl-2(0,
50%), bax(1+, <50%; 2+, 51-75%; 3+, >75%).
Results: Of the 35 cases, 16(45.7%) contained at least 1% bcl-2 positive tumor cells.
The bcl-2 positive cases included 1(7.7%) Gleason 2 to 4 grade tumors, 8(66.7%)
Gleason 5 to 7 tumors, 7(70.0%) Gleason 8 to 10 tumors. bel-2 protein expressed more
frequently in higher grade(p<0.05) and in higher PSA level(p<0.05) of tumors. lax
immunostaining was positive for all 35(100%) and 1+ was 16(45.7%), 2+ was 14(40.0%),
31 was 5(14.3%). But statistically significant differences in lax expression among grade,
T stage, and PSA were not observed. The bcl-2 protein was present mainly in the
basal cells, but bars was in both basal and secretory cells of prostate.
Conclusions: bcl-2 protein have some potential role in progression of prostate
carcinoma. Therefore, studies that evaluate the expression of these bcl-2 family genes in
varoius time during progression of tumors correlate with the state of hormone
dependency, response to therapy and duration of response are needed.
키워드
bcl-2; bax; Prostate carcinoma;
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