하부요로증상과 고혈압의 관계: 유병률 및 증상 분석
Relationship between Lower Urinary Tract Symptom and Hypertension: Coprevalence Rate and Symptom Severity
소속 상세정보
홍성준/Sung Joon Hong
정현직/나군호/허영숙/정병하/정신호/Hyun Jik Chung/Koon Ho Rha/Young Sook Huh/Byung Ha Chung/Sin Ho Jung
KMID : 0358319990400060729
Abstract
결론
본 연구 결과 우리나라 50세 이상 남성의 약 16%가 고혈압과 함께 치료를 요하는 하부요
로증상을 동반하고 있었으며, 전립선 비대증 환자에서 고혈압이 동반된 경우는 39.4%, 고혈
압 환자에서 하부요로증상을 동반한 경우는 53.2%를 나타냈다. 각 질환의 교차 검색 통한
분석 결과 고혈압과 하부요로증상은 동반 유병률에 있어서는 상호 연관성을 보이지 않았으
나, 고혈압의 유무가 IPSS에 유의한 영향을 미침을 확인하였다. 이러한 점을 고려할 때 남
성 고연령군에서 중요한 이들 질환에 대해 향후 국내에서도 치료약제 선택을 포함한 장기적
인 관리 지침의 수립이 반드시 필요하리라 생각된다.
Purpose: It Is presumed that lower urinary tract symptom(LUTS) and hypertension
are related to th8 age-dependent sympathetic activity. Thus, the attempt to elucidate a
correlation between these two conditions can be important in their management. We
investigated the relationship between LUTS and hypertension.
Materials and Methods: From 1995 to 1997, 1011 men(422 from routine physical
checkup, 288 benign prostatic hyperplasia(BPH) patients, 301 hypertension patients) over
50 years were enrolled. The international prostate symptom score(IPSS) and blood
pressure were recorded in all. 422 men from physical checkup were grouped into 4
categories according to the presence of LUTS(IPSS≥8) or hypertension(systolic≥
140mmHg, diastolic >90mmHg). The prevalence of hypertension, and the degree of
LUTS were evaluated. Statistical analysis was performed with t-test, chi-square test
and Mantel-Haenszel test.
Results: The prevalence of hypertension was not significantly different between the
LUTS(n=177) and non-LUTS groups(n=245)(38.4% vs 35.9%, p=0.600) in men from
physical checkup. There was no difference according to age(p=0.513). The prevalence of
hypertension was 39.6% in the BPH group(N=288) and was not different compared to
the non-LUTS group(n=245) (p=0.385). No significant difference in the prevalence of
LUTS was seen between hypertensives(n=156) and normotensives(n=266)(53.2% vs
48.2%, p=0.447) in the physical checkup group. However, their mean IPSS(8.9±6.5 vs 7.6
±5.6) were significantly different(p=0.030). The mean IPSS between hypertensives(15.21
±4.5) and normotensives(12.75±5.0) from the LUTS group(n=178) were significantly
different(p=0.002). The mean IPSS of the patients with hypertension(n=301, 9.6±5.9) was
significantly higher than normotensive men(n=266, 7.6±5.6) from physical
checkup(p=0.001).
Conclusions: Hypertension and LUTS including BPH do not correlate prevalence wise,
however, hypertension may affect the degree of IPSS.
키워드
BPH; Hypertension; Lower urinary tract symptom;
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