Wilms 종양의 예후인자와 술전 및 재발시 사용된 함암약물에 따른 생존율의 차이
Prognostic Factor and Survival Rate of Preoperative and Recurred CasesChemotherapy in Wilms' Tumor
소속 상세정보
1최영득/1Young Deuk
1한상원/1최승강/1고우진/1이중식/1이석영/2한석주/2황의호/3유철주/4김병수/1Sang Won Han/1Seung Kang Choi/1Woo Jin Ko/1Joong Shik Lee/1Suk Young Lee/2Suk Joo Han/2Eu Ho Hwang/3Chul Joo Yu/4Byung Soo Kim
KMID : 0358320000410060741
Abstract
-Abstract-
Purpose : We evaluated the prognostic factors of Wilms' tumor and reviewed the survival rate by several
chemotherapeutic d겨gs used in recurred group.
Materials and Methods : We reviewed the records of 53 patients with Wilms' tumor that had been treated
at the Yonsei University College of Medicine from Jan. 1970 to Jul. 1998. With regard to treatment,
radical nephrectomy combined with radiotherapy and chemotherapy was performed according to protocol.
In recurred group, we used cyclophosphamide, VP-16, cis-platinum, ifosfamide.
Results : Following the NWTS-III, there were I 21, II 10, III 12, IV 7 and V 3 with stages. There were
43(81.1%) favorable and 10 (18.9%) unfavorable type. Recurrence rates were I 14.2%, II 40.0%, III 25.0%,
IV 42.8%, V 33.3% with stages, favorable 11.6%, unfavorable 90% with histologic features. The survival
rates for those with stage were I 100%, II 64,3%, III 91.7%, IV 80.0%, V 66.7%. The survival rates for
those with favorable and unfavorable histologic features were 96.2% and 68.6%. There was no difference
in survival and recurrence rate according to age, symptoms and preoperative chemotherapy. In recurred
cases, no specific chemotherapeutic agent increased the survival rate of Wilm's tumor significantly.
Conclusions : The stage and histopathologic finding were important in the prognosis of Wilm's tumor, and
no specific chemotherapeutic agent showed to increase the survival rate significantly in recurred cases.
키워드
Wilm's tumor; Chemotherapy; Prognosis; Survival;
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