시클로포스파마이드로 유발된 백서방광의 배뇨근과활동성에 대한 보툴리눔독소와 레시니페라톡신의 효과에 관한 연구
The Effect of Botulinum Toxin and Resiniferatoxin on the Detrusor Overactivity Induced by Cyclophosphamide in Rat Bladder
김산욱, 심강수, 이정구,
소속 상세정보
김산욱 ( Kim San-Wook )
서울위생병원 비뇨기과
심강수 ( Shim Kang-Soo )
고려대학교 의과대학 비뇨기과학교실
이정구 ( Lee Jeong-Gu )
고려대학교 의과대학 비뇨기과학교실
KMID : 0358320060470010047
Abstract
Purpose: The purpose of this study was to compare the effects of resiniferatoxin(RTX) and botulinum toxin(BTX) on the bladder detrusor function in a cyclophosphamide(CYP)-induced cystitis rat model.
Materials and Methods: Sprague-Dawley rats were divided into 5 groups (1: saline treated, 2: CYP and BTX treated, 3: CYP and RTX treated, 4 and 5: CYP treated and sham operated as the counterpart of groups 2 and 3, respectively, with normal saline). 100mg/kg CYP was injected every third day for five weeks. Cystometrograms were performed after the BTX and RTX treatments.
Results: 1. The normal control group and the CYP-treated only group. In the CYP-treated group, the time of micturition frequency, the maximal detrusor pressure on the cystometergram(Pvesmax at CMG), the maximal detrusor pressure on the pressure-flow study(Pvesmax at pr/flow) and the episodes of irregular contractions were increased. 2. The CYP-only group and the CYP/BTX or CYP/RTXtreated groups. In the CYP/BTX or CYP/RTX treated groups, the time of micturition frequency, the Pvesmax at CMG, the Pvesmax at pr/flow and the episode of irregular contractions were decreased. 3. The CYP/BTXtreated group and the CYP/ RTXtreated group. There was no statistically significant difference between the two groups regarding micturition frequency, the PvesMax at CMG and the PvesMax at pr/flow, the Dhfo and the episodes of involuntary contractions(p＞0.05).
Conclusions: Intravesical administration of BTX or RTX blocked the CYP-induced detrusor overactivity as was shown by the restoration of the micturition frequency, the intravesical pressure and the involuntary contraction episodes to a control level. There was no statistically significant difference between the two groups regarding the urodynamic parameters. (Korean J Urol 2006;47:47-54)
키워드
Botulinum toxins;Resiniferatoxin;Cyclophosphamide
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