방광암에서 E2F3 발현의 예후인자로서의 의미
Prognostic Significance of E2F3 Expression in Bladder Cancer
문홍상, 장기석, 백승삼, 이행남, 박성열, 김기영, 김선일, 최홍용, 박해영, 이춘용, 우영남,
소속 상세정보
문홍상 ( Moon Hong-Sang )
한양대학교 의과대학 비뇨기과학교실
장기석 ( Jang Ki-Seok )
한양대학교 의과대학 병리학교실
백승삼 ( Paik Seung-Sam )
한양대학교 의과대학 병리학교실
이행남 ( Lee Haeng-Nam )
한양대학교 의과대학 비뇨기과학교실
박성열 ( Park Sung-Yul )
한양대학교 의과대학 비뇨기과학교실
김기영 ( Kim Gi-Young )
한양대학교 의과대학 비뇨기과학교실
김선일 ( Kim Sul-Il )
한양대학교 의과대학 비뇨기과학교실
최홍용 ( Choi Hong-Yong )
한양대학교 의과대학 비뇨기과학교실
박해영 ( Park Hae-Young )
한양대학교 의과대학 비뇨기과학교실
이춘용 ( Lee Tchun-Yong )
한양대학교 의과대학 비뇨기과학교실
우영남 ( Woo Young-Nam )
한양대학교 의과대학 비뇨기과학교실
KMID : 0358320060470010075
Abstract
Purpose: E2F3 is important for cell cycle regulation and DNA replication. Recent studies have reported that members of the E2F family can play specific and diverse roles in the tumorigenesis of human malignancies, and the E2F3 expression appears to provide a growth advantage to tumor cells by activating cell proliferation in bladder tumors. We studied the prognostic significance of E2F3 expression in bladder cancer.
Materials and Methods: We examined the expression of E2F3 with using immunohistochemical staining in the tumor samples from 109 patients suffering with bladder cancer, and we analyzed the prognostic significance of E2F3 according to the grade, stage, recurrence and progression of bladder cancer.
Results: We found positive staining for E2F3 in 23 cases(21.1%). The E2F3 expression was correlated with the tumor stage (superficial vs. invasive, p＜0.001) and the tumor grade(p=0.001). The E2F3 expression was not correlated with the recurrence and progression of superficial bladder cancer.
Conclusions: In this study, our results showed that the E2F3 expression was observed in a portion of the bladder cancer specimens. These results suggest that E2F3 may contribute to the development of bladder cancer, but it may not play a role as a prognostic factor of bladder cancer. (Korean J Urol 2006;47:75-79)
키워드
E2F3 transcription factor;Bladder cancer
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