신세포암에서 종양 혈관형성 및 미세혈관침범의 예후적 가치
Prognostic Value of Tumor Angiogenesis and Microvascular Invasion in Renal Cell Carcinoma
조대성, 임현이, 오동근, 강지훈, 김영수, 김세중,
소속 상세정보
조대성 ( Cho Dae-Sung )
아주대학교 의과대학 비뇨기과학교실
임현이 ( Yim Hyun-Ee )
아주대학교 의과대학 병리학교실
오동근 ( Oh Dong-Keun )
아주대학교 의과대학 비뇨기과학교실
강지훈 ( Kang Ji-Hun )
아주대학교 의과대학 비뇨기과학교실
김영수 ( Kim Young-Soo )
아주대학교 의과대학 비뇨기과학교실
김세중 ( Kim Se-Joong )
아주대학교 의과대학 비뇨기과학교실
KMID : 0358320060470020111
Abstract
Purpose: This study was performed to evaluate the impact of microvessel density(MVD), a reflection of tumor angiogenesis, and microvascular invasion(MVI) on the prognosis of patients with renal cell carcinoma(RCC).
Materials and Methods: Formalin-fixed, paraffin-embedded tissue sections of RCC from 81 patients who had undergone radical nephrectomy were stained immunohistochemically for CD34, which decorate endothelial cells, in order to assess MVD and MVI. The immunostaining results of MVD and MVI were compared with the clinicopathological variables.
Results: Twenty-two patients had either synchronous or metachronous metastases and fourteen patients died during the follow-up. MVD was significantly correlated with only metastasis(synchronous or metachronous; p=0.020). MVI was significantly correlated with tumor size(p=0.005), TNM stage(p＜0.001), T stage(p＜0.001), M stage(p=0.001), and metastasis(synchronous or metachronous; p=0.007). MVD was not significantly associated with MVI(p=0.232). The survival rate of patients with higher MVD or MVI-positive tumors was significantly lower than that of patients with lower MVD or MVI-negative tumors, respectively(p＜0.0001, p=0.0002). Multivariate analyses indicated that tumor size, M stage and MVI were independent prognostic factors for cancer-specific survival. MVD was not an independent factor.
Conclusions: MVD and MVI were associated with metastasis and a worse prognosis in RCC, which suggests that tumor angiogenesis and MVI may play an important role in the progression of RCC. MVI was an independent prognostic factor for cancer-specific survival.
키워드
Renal cell carcinoma;Prognosis;Veins
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