가토의 전립선에서 신경내분비세포와 Survivin의 발현
Expression Pattern of Neuroendocrine Cells and Survivin in the Prostate of Rabbits
김준모, 이광우, 김영호, 고은석, 김민의, 이남규,
소속 상세정보
김준모 ( Kim Jun-Mo )
순천향대학교 의과대학 비뇨기과학교실
이광우 ( Lee Kwang-Woo )
순천향대학교 의과대학 비뇨기과학교실
김영호 ( Kim Young-Ho )
순천향대학교 의과대학 비뇨기과학교실
고은석 ( Koh Eun-Seok )
순천향대학교 의과대학 병리학교실
김민의 ( Kim Min-Eui )
순천향대학교 의과대학 비뇨기과학교실
이남규 ( Lee Nam-Kyu )
순천향대학교 의과대학 비뇨기과학교실
KMID : 0358320060470020201
Abstract
Purpose: The neuroendocrine cell(NE cell) is thought to play an important role in the development of hormone-refractory prostate cancer. Survivin is one of the IAPs(inhibitors of apoptosis), and it is expressed in the NE cell and in most of the common cancers, but not in normal tissue. The objective of this study was to investigate the expression pattern of the NE cell and survivin in the prostate of rabbits.
Materials and Methods: The 9 rabbits underwent orchiectomy and their prostates were removed at 0 weeks(control), 2 weeks and 6 weeks after orchiectomy. Each of the prostatic tissue specimens was stained with H&E; immunohistochemical staining was done for chromogranin A, synaptophysin and survivin, and the tissue specimens were then examined by microscopy.
Results: In the prostate of rabbits, most of the NE cells were located between the epithelial gland and the stroma. NE differentiation occurred 6 weeks after orchiectomy. The location of cells that were positive for survivin was almost same as that of the NE cells.
Conclusion: The main location of NE cells in the prostate of rabbits was between the epithelial gland and the stroma, and NE differentiation occurred 6 weeks after orchiectomy, the same as in a human or a dog. The location of survivin positive cells coincided with that of the NE cells. Therefore, a rabbit seems to be a suitable animal model for the study of the NE cell. (Korean J Urol 2006;47:201-205)
키워드
APUD cells;Survivin;Prostate;Orchiectomy;Rabbits
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