척수손상 흰쥐에서 방광 내 전기자극치료의 효과 및 기전
The Effect and Mechanism of Intravesical Electrical Stimulation in Spinal Cord Injured Rats
전형진, 김매화, 고혜경, 홍창희, 김장환, 한상원,
소속 상세정보
전형진 ( Jeon Hyung-Jin )
연세대학교 의과대학 비뇨기과학교실
김매화 ( Jin Mei-Hua )
연세대학교 의과대학 BK21 의과학사업단
고혜경 ( Ko Hae-Kyung )
연세대학교 의과대학 BK21 의과학사업단
홍창희 ( Hong Chang-Hee )
한림대학교 의과대학 비뇨기과학교실
김장환 ( Kim Jang-Hwan )
연세대학교 의과대학 비뇨기과학교실
한상원 ( Han Sang-Won )
연세대학교 의과대학 비뇨기과학교실, 비뇨의과학연구소
KMID : 0358320060470030303
Abstract
Purpose: The objective of this study was to evaluate whether the effect on afferent c-fiber activity is the underlying mechanism of intravesical electrical stimulation(IVES) in spinal cord injured rats.
Materials and Methods: Thirty five female Sprague-Dawley rats weighting 200-300g each were divided into the normal and spinalized groups. For the spinalized rats, we observed the c-fos expression, and we compared this in the non-IVES group with that in the IVES group. Cystometrograms were performed for all the groups via a suprapubic catheter.
Results: After performing IVES in the normal and spinalized rats, the abnormal increases of the intercontraction interval(ICI) and the voiding pressure(VP) were reduced close to the normal range. In the spinalized rats, the number of c-fos positive cells in the dorsal commissure(DCM) decreased in the group that had IVES performed when compared with the non-IVES group.
Conclusion: The IVES reduced the c-fos gene expression in the L6-S1 spinal cord segment and also the bladder hyperreflexia in the spinalized rats through the inhibition of afferent c-fiber activity, in addition to affecting the Aδ mechanoreceptors. (Korean J Urol 2006;47:303-309)
키워드
Electrical stimulation;c-fos;Spinal cord injuries;Rats
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