전립선특이항원치가 4.0-10.0ng/ml인 한국남성에서 나이와 전립선 용적이 전립선암 발견율에 미치는 영향: 다기관, 후향적 연구
The Influence of Age and Prostate Volume on the Cancer Detection Rate in Korean Men with PSA Levels of 4.0 to 10.0ng/ml: a Multicenter, Retrospective Study
성도환, 조진선, 홍성준, 정병하, 최영득, 김세중, 이동현, 조인래, 김영식, 김천일, 김선일, 송재만, 전상현, 김홍섭,
소속 상세정보
성도환 ( Seong Do-Hwan )
인하대학교 의과대학 비뇨기과학교실
조진선 ( Cho Jin-Seon )
한림대학교 의과대학 비뇨기과학교실
홍성준 ( Hong Sung-Joon )
연세대학교 의과대학 비뇨기과학교실
정병하 ( Chung Byung-Ha )
연세대학교 의과대학 비뇨기과학교실
최영득 ( Choi Young-Deuk )
연세대학교 의과대학 비뇨기과학교실
김세중 ( Kim Se-Joong )
아주대학교 의과대학 비뇨기과학교실
이동현 ( Lee Dong-Hyun )
이화여자대학교 의과대학 비뇨기과학교실
조인래 ( Cho In-Rae )
인제대학교 의과대학 비뇨기과학교실
김영식 ( Kim Young-Sig )
국민건강보험공단 일산병원 비뇨기과학교실
김천일 ( Kim Chun-Il )
계명대학교 의과대학 비뇨기과학교실
김선일 ( Kim Sul-Il )
한양대학교 의과대학 비뇨기과학교실
송재만 ( Song Jae-Mann )
연세대학교 원주의과대학 비뇨기과학교실
전상현 ( Cheon Sang-Hyeon )
울산대학교 의과대학 비뇨기과학교실
김홍섭 ( Kim Hong-Sup )
건국대학교 의과대학 비뇨기과학교실
KMID : 0358320060470040353
Abstract
Purpose: We retrospectively investigated how patients age and prostate volume influence on the cancer detection rate in Korean men with prostate-specific antigen (PSA) levels of 4.0 to 10.0ng/ml.
Materials and Methods: 791 Korean men who underwent transrectal ultrasound guided prostate biopsies(TRBx) at 12 medical centers were analyzed retrospectively during the previous 10 years. TRBx were performed in cases with PSA levels of 4.0 to 10.0ng/ml. The biopsy-proven cancer patient group was compared to the non-cancer patient group according to age, PSA, prostate volume and PSAD.
Results: Among the 791 patients who underwent TRBx, prostate cancer was detected in 123 patients (15.5%). The mean age(cancer group vs non-cancer group=69.1 vs 63.8 year-old), prostate volume (38.0 vs 42.5ml, respectively) and PSAD(0.21 vs 0.18ng/ml/ml, respectively) were found in statistically significant between the two groups. The cancer detection rate(20.1%) in the small prostate (less than 40ml) was significantly higher than that(10.3%) of the large prostate. The cancer detection rate was significantly increased with age: from 14.4% for the 50 to 59 year-old patients to 31.6% for the 80 or more year-old patients.
Conclusions: The cancer detection rate in Korean men with a gray zone PSA level is lower than that of Caucasians. However, regarding the detection of prostate cancer in Korean men, the older age group and the patients with less than 40ml of prostate volume among the patients with gray zone PSA levels are considered as the important factors to decide whether biopsy of prostate is needed. (Korean J Urol 2006;47:353-357)
키워드
Prostate-specific antigen;Prostate;Prostate cancer
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