전립선특이항원 수치가 3.0-4.0ng/ml인 환자군과 4.1-10.0ng/ml인 환자군 사이에서 전립선암의 진단율 및 병리학적 특성의 비교
Comparison of the Rate of Detecting Prostate Cancer and the Pathologic Characteristics of the Patients with a Serum PSA Level in the Range of 3.0 to 4.0ng/ml and the Patients with a Serum PSA Level in the Range 4.1 to 10.0ng/ml
박형근, 홍성규, 변석수, 이상은,
소속 상세정보
박형근 ( Park Hyoung-Keun )
동국대학교 의과대학 비뇨기과학교실
홍성규 ( Hong Sung-Kyu )
서울대학교 의과대학 비뇨기과학교실
변석수 ( Byun Seok-Soo )
서울대학교 의과대학 비뇨기과학교실
이상은 ( Lee Sang-Eun )
서울대학교 의과대학 비뇨기과학교실
KMID : 0358320060470040358
Abstract
Purpose: We prospectively evaluated the prostate cancer detection rate and pathologic characteristics of patients with a serum prostate-specific antigen(PSA) level of 3.0 to 4.0ng/ml and we compared this with the patients who had a PSA level in the range of 4.1 to 10.0ng/ml.
Materials and Methods: We analyzed the data of patients who had PSA levels of 3.0 to 10.0ng/ml, benign findings on digital rectal examination (DRE) and no specific lesion identified on transrectal ultrasound. The clinical characteristics, cancer detection rate and pathologic findings of the biopsy and prostatectomy specimen were compared between the low(3.0 to 4.0ng/ml) and intermediate(4.1 to 10.0ng/ml) PSA groups.
Results: A total of 370 patients met our criteria and so they were included in the study. Sixty five and 305 patients had low or intermediate PSA levels, respectively. The mean age and the number of prostate biopsy cores were not different between the two groups. Prostate cancer was diagnosed in 26% of the low PSA group and in 20% of the intermediate PSA group. No significant difference was found between the two groups on the pathologic findings of the biopsy and on the pathology findings of the prostatectomy specimens, including the mean Gleason score, the percentage of patients with a Gleason score 7 or higher, the pathologic stage and the percentage of insignificant prostate cancer.
Conclusions: No statistically significant difference was found in the incidence of prostate cancer or pathological characteristics on comparison between the low and intermediate PSA groups. These results suggest that a lower PSA cutoff should be considered as an indication for a prostate biopsy in the Korean population. (Korean J Urol 2006;47:358-361)
키워드
Prostate-specific antigen;Prostate cancer;Biopsy
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