건강한 젊은 남성과 중년 남성에서 성적 자극에 의한 뇌의 활성화 비교
Difference of Brain Activation by Visual Erotic Stimuli in Young and Middle-aged Healthy Males
손동완, 조강준, 김효신, 이충범, 강성학, 조용현, 윤문수, 채정호, 김세웅,
소속 상세정보
손동완 ( Sohn Dong-Wan )
가톨릭대학교 의과대학 비뇨기과학교실
조강준 ( Cho Kang-Jun )
가톨릭대학교 의과대학 비뇨기과학교실
김효신 ( Kim Hyo-Sin )
가톨릭대학교 의과대학 비뇨기과학교실
이충범 ( Lee Chung-Bum )
가톨릭대학교 의과대학 비뇨기과학교실
강성학 ( Kang Sung-Hak )
가톨릭대학교 의과대학 비뇨기과학교실
조용현 ( Cho Yong-Hyun )
가톨릭대학교 의과대학 비뇨기과학교실
윤문수 ( Yoon Moon-Soo )
가톨릭대학교 의과대학 비뇨기과학교실
채정호 ( Chae Jeong-Ho )
가톨릭대학교 의과대학 정신과학교실
김세웅 ( Kim Sae-Woong )
가톨릭대학교 의과대학 비뇨기과학교실
KMID : 0358320060470050517
Abstract
Purpose: The objectives of this study are to identify the brain centers whose activity changes are related to sexually arousing visual stimuli and to identify the difference between young and middle-aged males by mapping the brain activity with using blood oxygen level dependent functional magnetic resonance imaging(BOLD-fMRI).
Materials and Methods: Ten young heterosexual, right handed males with normal sexual function(mean age: 27 years, age range: 24 to 31) and ten middle-aged heterosexual, right handed males with normal sexual function(mean age: 52 years, age range: 46 to 55) were enrolled into this study. Real-time visual stimulation was performed with the subjects alternatively viewing erotic and non-erotic films to identify the activated brain regions associated with sexual response. Assessments with using a five-point scale were determined after visual stimulation to evaluate the subjective sexual arousal. Brain activity was mapped by performing BOLD-fMRI on a 1.5T MR scanner. After functional scanning, the high-resolution data was analyzed with the SPM analyzing program; the significance of activation was set at p＜0.01 or p＜0.001.
Results: The parietal lobe, frontal lobe, cingulate gyrus, caudate nucleus, thalamus and hypothalamus were noted as the areas of activation specifically associated with viewing the erotic film segments by the young males. For the middle-aged males, these areas were the parietal lobe, frontal lobe, right temporal lobe, cingulate gyrus and caudate nucleus. The thalamus and hypothalamus were activated in only the young males.
Conclusions: We suggest that the non-activation of the hypothalamus and thalamus in middle-aged males may be associated with the lesser physiological arousal in response to the erotic visual stimuli. The non-invasive visualization of the central nervous system by functional MRI in healthy males has shown the possibility for evaluating the neuroanatomy of the brain that is associated with sexual arousal and its clinical application by comparing young and middle-aged males. (Korean J Urol 2006;47:517-521)
키워드
Brain;MRI;Sex
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