한국인에서 혈중 전립선특이항원의 연령별 정상치
Age-Specific Reference Ranges for Serum Prostate- Specific Antigen in Korean Men
전형진, 김영식, 강대룡, 남정모, 김천일, 성도환, 김세중, 전상현, 조인래, 조진선, 홍성준, 최영득,
소속 상세정보
전형진 ( Jeon Hyung-Jin )
연세대학교 의과대학 비뇨기과학교실
김영식 ( Kim Young-Sig )
국민건강보험공단 일산병원 비뇨기과
강대룡 ( Kang Dae-Ryong )
연세대학교 의과대학 예방의학교실
남정모 ( Nam Chung-Mo )
연세대학교 의과대학 예방의학교실
김천일 ( Kim Chun-Il )
계명대학교 의과대학 비뇨기과학교실
성도환 ( Seong Do-Hwan )
인하대학교 의과대학 비뇨기과학교실
김세중 ( Kim Se-Joong )
아주대학교 의과대학 비뇨기과학교실
전상현 ( Cheon Sang-Hyeon )
울산대학교 의과대학 비뇨기과학교실
조인래 ( Cho In-Rae )
인제대학교 의과대학 비뇨기과학교실
조진선 ( Cho Jin-Seon )
한림대학교 의과대학 비뇨기과학교실
홍성준 ( Hong Sung-Joon )
연세대학교 의과대학 비뇨기과학교실
최영득 ( Choi Young-Deuk )
연세대학교 의과대학 비뇨기과학교실
KMID : 0358320060470060586
Abstract
Purpose: The level of serum prostate-specific antigen(PSA) varies according to both age and race. It is known that the level of PSA increases with age, and that Asians have a lower incidence of prostate cancer and levels of PSA than Caucasians. In this study, the variation in the serum PSA level in samples collected from general populations were used to find an actual standard age-specific PSA reference range for Koreans.
Materials and Methods: Patients who received serum PSA level check- ups, between November 1998 and July 2005, at 8 domestic hospitals, were selected for the investigation. The PSA levels of 120,439 adult males, aged between 30 and 80 years, were measured, and those lower than 10ng/ml were analyzed. To estimate the increase in the level of serum PSA according to age, a simple linear regression analysis was carried out.
Results: The mean PSA level reference ranges according to age were 1.88, 1.92, 2.37, 3.56 and 5.19ng/ml for those in their thirties, forties, fifties, sixties and seventies, respectively. The rates of PSA change were 0.0023, 0.0175 and 0.0499 for those in their forties, fifties and sixties, respectively, indicating the rates of PSA level change increase steady with age, but these increases are greater for those in their fifties and most severe after their sixties. The level of age-specific PSA reference in Korean men was lower than that of men from Western countries.
Conclusions: The age-specific PSA reference levels, as found in pre-existing literature, showed differences between races, with the overall reference levels being low for domestic data. The standard reference level of age- specific PSA for the screening of prostate cancer may be lower in Korean men than those from Western countries. (Korean J Urol 2006;47:586-590)
키워드
Prostate-specific antigen;Age groups;Screening;Reference range
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