신세포암에서 Tissue Microarray를 이용하여 분석한 Caveolin-1 발현과 예후와의 연관성
Correlation of Caveolin-1 Expression on Tissue Microarray with Prognosis in Renal Cell Carcinoma
원용연, 주희재, 조대성, 김기훈, 서경식, 안병철, 김세중,
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원용연 ( Won Yong-Yeun )
아주대학교 의과대학 비뇨기과학교실
주희재 ( Joo Hee-Jae )
아주대학교 의과대학 병리학교실
조대성 ( Cho Dae-Sung )
아주대학교 의과대학 비뇨기과학교실
김기훈 ( Kim Ki-Hoon )
아주대학교 의과대학 비뇨기과학교실
서경식 ( Seo Kyung-Sik )
아주대학교 의과대학 비뇨기과학교실
안병철 ( Ahn Byung-Cheol )
아주대학교 의과대학 비뇨기과학교실
김세중 ( Kim Se-Joong )
아주대학교 의과대학 비뇨기과학교실
KMID : 0358320060470060607
Abstract
Purpose: We investigated the relationship between the expression of caveolin-1, using a tissue microarray(TMA), and the prognosis of patients with renal cell carcinoma(RCC).
Materials and Methods: TMA sections of formalin-fixed, paraffin-embedded tissues of RCC from 82 patients, who had undergone radical nephrectomy, were stained immunohistochemically with specific antibodies against caveolin-1. The caveolin-1 immunostaining was semi-quantitatively estimated based on intensity. The expression pattern of caveolin-1 was compared with the clinicopathological variables.
Results: The expression of caveolin-1 was significantly correlated with tumor size(p=0.002), TNM stage(p＜0.001), T stage(p=0.001), M stage (p=0.004), grade(p=0.028) and metastasis(p＜0.001), and was also significantly higher in clear cell than non-clear cell RCC(p＜0.001). The survival of patients with higher caveolin-1 expression was significantly worse than that of patients with lower caveolin-1 expression(p=0.001). Univariate analyses were able to identify all variables, including caveolin-1 expression as significant prognostic factors for cancer-specific survival; multivariate analyses indicated that TNM stage, M stage and grade were independent prognostic factors. Caveolin-1 expression was not an independent factor.
Conclusions: The increased expression of caveolin-1 is associated with tumor size, stage, grade, metastasis and a worse prognosis in RCC, which suggests that caveolin-1 may be important in the progression of RCC. (Korean J Urol 2006;47:607-613)
키워드
Caveolin-1;Tissue microarray;Prognosis;Renal cell carcinoma
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