전립선암 조직에서의 Peroxisome Proliferator-Activated Receptor(PPAR)α, PPARγ 및 Phosphoglycerate Mutase 2의 발현 감소
Downregulation of Peroxisome Proliferator-Activated Receptor(PPAR)α, PPARγ, and Phosphoglycerate Mutase 2 in Prostate Cancer
조혁진, 김덕윤, 김정욱, 유탁근, 양은경,
소속 상세정보
조혁진 ( Cho Hyuk-Jin )
대구가톨릭대학교 의과대학 비뇨기과학교실
김덕윤 ( Kim Duk-Yoon )
대구가톨릭대학교 의과대학 비뇨기과학교실
김정욱 ( Kim Jung-Wook )
경북대학교 의과대학 생리학교실
유탁근 ( Yoo Tag-Keun )
을지대학교 의과대학 비뇨기과학교실
양은경 ( Yang Eun-Kyoung )
경북대학교 의과대학 생리학교실
KMID : 0358320060470060661
Abstract
Purpose: To evaluate whether factors related to lipid and glucose metabolism have a potential role in the progression of prostate cancer, we measured the mRNA levels of the peroxisome proliferator-activated receptor(PPAR), fatty acid elongase(ELOVL), and two glycolytic enzymes in prostate cancer(CaP) tissues.
Materials and Methods: Prostate tissues, obtained from radical prostatectomy(n=10) and transurethral resection of prostate(n=18), were quickly frozen in liquid nitrogen for RNA measurements. Transcript signals of PPARα, PPARγ, ELOVL2, ELOVL5, phosphoglycerate kinase 1(PgK1) and phosphoglycerate mutase 2(PgM2) were measured using a reverse- transcription polymerase chain reaction.
Results: The transcript signals of PPARα and PPARγ were down-regulated in CaP tissues. In addition, the mRNA level of PgM2 in CaP tissues was lower than that in benign prostatic hyperplasia(BPH) tissues. However, the messages for ELOVL2, ELOVL5, and PgK1 were not significantly changed.
Conclusions: These results suggest that lowering of the PPARα, PPARγ and PgM2 messages may be involved in aberrant and uncontrolled prostate cell growth and differentiation. (Korean J Urol 2006;47:661-666)
키워드
Prostate cancer;Peroxisome proliferator-activated receptors;Phosphoglycerate mutase
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