인체 신세포암에서 Clusterin 발현과 Ki-67 발현 및 병리학적 특성과의 관계
The Relationship of Clusterin Expression with Ki-67 Expression and Clinicopathological Factors in Human Renal Cell Carcinoma
박현철, 이완, 이상돈, 김정만, 이창렬, 이정주, 정문기,
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박현철 ( Park Hyun-Cheol )
부산대학교 의과대학 비뇨기과학교실
이완 ( Lee Wan )
부산대학교 의과대학 비뇨기과학교실
이상돈 ( Lee Sang-Don )
부산대학교 의과대학 비뇨기과학교실
김정만 ( Kim Jung-Man )
부산대학교 의과대학 비뇨기과학교실
이창렬 ( Lee Chang-Yell )
부산대학교 의과대학 비뇨기과학교실
이정주 ( Lee Jeong-Zoo )
부산대학교 의과대학 비뇨기과학교실
정문기 ( Chung Moon-Kee )
부산대학교 의과대학 비뇨기과학교실
KMID : 0358320070480030244
Abstract
Purpose: This study was performed to evaluate the relationship of the expressions of clusterin with Ki-67 and the clinicopathological factors and significance of clusterin expression in human renal cell carcinoma(RCC).
Materials & Methods: Normal kidney(n=26) and RCC tissues(n=111) were obtained from 111 patients who had undergone a radical or partial nephrectomy. The expressions of clusterin and Ki-67 protein were analysed using immunohistochemical staining. The medical records of the patients were retrospectively reviewed to evaluate the clinicopathological factors.
Results: In contrast to the clusterin and Ki-67 expressions of 30.8 and 11.5%, respectively in the normal kidney(n=26), those in the RCC tissues were 93.7 and 28.8%(n=111), respectively(p＜0.05). In contrast to the normal tissues, Ki-67 staining was significantly correlated with the expression of clusterin in the RCC tissues(p＜0.05). The expression level of clusterin protein in the RCC tissues was significantly related to the tumor stage and grade(p＜0.05), but not to age, gender or histological cell type(p＞0.05). Furthermore, the recurrence-free survival in patients with strong clusterin expression was significantly lower than in those with weak expression(p＜0.05).
Conclusion: These findings suggest that clusterin may be involved in the progression of RCC and; therefore, a useful prognostic variable in patients with an RCC.(Korean J Urol 2007;48:244-251)
키워드
Renal cell carcinoma;Clusterin;Ki-67 antigen;Clinicopathological factor
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