신우신염 흰쥐모델에서 표고버섯(Lentinus Edodes)의 신반흔 억제효과
The Suppressive Effect of Lentinus Edodes on Renal Scarring Secondary to Pyelonephritis
이영국, 박관규, 신정임, 신임희, 박재신,
소속 상세정보
이영국 ( Lee Young-Guk )
대구가톨릭대학교 의과대학 비뇨기과학교실
박관규 ( Park Kwan-Kyu )
대구가톨릭대학교 의과대학 병리학교실
신정임 ( Shin Jung-Im )
대구가톨릭대학교 의과대학 조직공학교실
신임희 ( Shin Im-Hee )
대구가톨릭대학교 의과대학 의학통계학교실
박재신 ( Park Jae-Shin )
대구가톨릭대학교 의과대학 의학통계학교실
KMID : 0358320070480030315
Abstract
Purpose: Lentinus edodes is used in both foods and drugs, and is also known to be an antioxidant agent. Some investigators have noted that renal scarring following pyelonephritis is closely related to inflammation or free oxygen radicals, rather than to direct injury due to bacterial infection. The efficiency of the antioxidant agent, lentinus edodes, in preventing the renal scarring caused by experimental pyelonephritis was evaluated in rats.
Materials & Methods: Twenty eight male Sprague Dawley rats(n=28) were injected into both renal parenchyma with 0.1ml of a solution containing Escherichia coli(108/ml). The control group, consisting of 4 rats, received an injection of isotonic saline instead of the bacterial solution. Three days after surgery, the animals were given the following treatments: in the pyelonephritis group, 7 rats received isotonic saline for 5 days; in the antibiotics treatment group, 6 rats were treated with an antibiotic only, ciprofloxacin, for 5 days. In the lentinus edodes treatment group, 5 rats were treated with lentinus edodes only. In the combined group, 6 rats received both lentinus edodes and ciprofloxacin. The kidneys were harvested 6 weeks after infection, and histopathologically examined for renal scarring.
Results: Delayed treatment with antibiotics-only or lentinus edodes-only had no effect on the scarring compared with the untreated controls. However, the addition of lentinus edodes to the delayed antibiotic therapy significantly inhibited the renal scarring compared with the pyelonephritis, antibiotic-only treated and the lentinus edodes-only treated groups(p＜0.05).
Conclusion: The administration of lentinus edodes in combination with antibiotics significantly reduced the renal scar formation in pyelonephritis. (Korean J Urol 2007;48:315-320)
키워드
Lentinus edodes;Pyelonephritis
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