상부요로 이행세포암에서 Cyclooxygenase-2 발현 및 미세혈관 밀도와 예후와의 연관성
Correlation of Cyclooxygenase-2 Expression and Microvessel Density with Prognosis in Transitional Cell Carcinoma of the Upper Urinary Tract
차민호, 조강수, 홍성준, 조대성, 임현이, 조남훈, 김선일, 안현수, 김세중,
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차민호 ( Cha Min-Ho )
아주대학교 의과대학 비뇨기과학교실
조강수 ( Cho Kang-Su )
연세대학교 의과대학 비뇨기과학교실, 비뇨의과학연구소
홍성준 ( Hong Sung-Joon )
연세대학교 의과대학 비뇨기과학교실, 비뇨의과학연구소
조대성 ( Cho Dae-Sung )
아주대학교 의과대학 비뇨기과학교실
임현이 ( Yim Hyun-Ee )
아주대학교 의과대학 병리학교실
조남훈 ( Cho Nam-Hoon )
아주대학교 의과대학 병리학교실
김선일 ( Kim Sun-Il )
아주대학교 의과대학 비뇨기과학교실
안현수 ( Ahn Hyun-Soo )
아주대학교 의과대학 비뇨기과학교실
김세중 ( Kim Se-Joong )
아주대학교 의과대학 비뇨기과학교실
KMID : 0358320070480040376
Abstract
Purpose: The aim of this study was to investigate the relationship of cyclooxygenase(COX)-2 expression and microvessel density(MVD), a reflection of angiogenesis, with prognosis in patients with transitional cell carcinoma of the upper urinary tract(TCC-UUT).
Materials & Methods: Formalin-fixed, paraffin-embedded tissue sections of TCC-UUT from 91 patients, who had undergone radical nephroureterectomy, were examined immunohistochemically using antibodies against COX-2 and CD34. MVD was determined with CD34-stained slides. The expression patterns of COX-2 and MVD were compared with the clinicopathological variables.
Results: The COX-2 expression was significantly correlated with T stage (p=0.002), N stage(p=0.010), and grade(p=0.027). MVD was also significantly correlated with T stage(p＜0.001), N stage(p=0.002), and grade (p=0.001). The COX-2 expression was significantly correlated with MVD (p=0.001). The survival rate of patients with COX-2 positive tumors or high MVD was significantly lower than that of patients with COX-2 negative tumors or low MVD, respectively(p=0.0013, p=0.0312). Univariate analyses identified T stage, N stage, grade, COX-2 expression, and MVD as significant prognostic factors for cancer-specific survival; multivariate analyses indicated that T stage was the only independent prognostic factor.
Conclusion: The increased expression of COX-2 and MVD is associated with a worse prognosis in TCC-UUT. The COX-2 expression is correlated with MVD. These results suggest that COX-2 may play an important role in the progression of TCC-UUT and angiogenesis may be affected by COX-2 during the progression of TCC-UUT. (Korean J Urol 2007;48: 376-382)
키워드
Cyclooxygenase 2;Prognosis;Transitional cell carcinoma;Urinary tract
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