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¹æ±¤¾Ï¿¡¼­ NF-¥êB¿Í Apoptosis À¯¹ß À¯ÀüÀڵ鿡 °üÇÑ ºÐ¼® Analysis of the NF-¥êB and Apoptosis Inducing Genes in Bladder Tumor

´ëÇѺñ´¢±â°úÇÐȸÁö 2007³â 48±Ç 5È£ p.483 ~ 488
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Á¤ÇʵΠ( Jung Pil-Du ) 
Chungbuk National University

±è¿ëÁØ ( Kim Yong-June ) 
Chungbuk National University
ÀÌ»óö ( Lee Sang-Cheol ) 
Chungbuk National University
±è¿øÀç ( Kim Wun-Jae ) 
Chungbuk National University
À±¼®Áß ( Yun Seok-Joong ) 
Chungbuk National University
Çѱ¤Èñ ( Han Kwang-Hee ) 
Chungbuk National University
ÀÌÇü·¡ ( Lee Hyung-Lae ) 
°æÈñ´ëÇб³ ÀÇ°ú´ëÇÐ ºñ´¢±â°úÇб³½Ç

Abstract


Purpose: A multi-subunit transcription factor NF-¥êB mediates the antiapoptotic signals in several cancer cell lines and it is activated in a broad range of human tumors. In this study, we investigated whether the expression levels of the NF-¥êB and the apoptosis inducing genes were related to the pathogenesis and clinical properties of human bladder tumor.

Materials and Methods: The expressions of NF-¥êB, BCL2-associated X protein(BAX), BCL2-associated death protein(BAD) and BH3-interacting domain death agonist protein(BID) were investigated by performing immunohistochemical staining on 133 archival bladder tissue paraffin blocks; these blocks included 122 transitional cell carcinomas of the urinary bladder and 11 normal bladder mucosae.

Results: The expression levels of NF-¥êB were significantly higher in the bladder tumors than those of the normal bladder mucosae(p=0.001). The expression levels of BAX in the superficial and low-grade(grade 1 and 2) bladder tumors were significantly enhanced more than those of the high-grade and invasive cases(p=0.042 and p=0.045, respectively), while the expression levels of BAD in the tumor tissues and low-grade tumors were significantly elevated compared with those of the normal mucosae and high grade tumor(p=0.007 and p=0.048, respectively). But the expressions of BID were not correlated with any pathologic and clinical properties.

Conclusions: The expressions of the NF-¥êB and apoptosis inducing genes such as BAX and BAD are strongly associated with the pathogenesis and clinical properties of bladder tumor. (Korean J Urol 2007;48:483-488)

Å°¿öµå

NF-¥êB;BCL2-associated X protein;BCL2-associated death protein;BH3 interacting domain death agonist protein;Bladder tumor

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