대사증후군이 동반된 전립선암의 종양학적 특징
The Characteristics of Prostate Cancer with Metabolic Syndrome in Korean Men
한병규, 최우석, 유지형, 한준현, 장인호, 정성진, 홍성규, 변석수, 이상은,
소속 상세정보
한병규 ( Han Byoung-Kyu )
분당서울대학교병원 비뇨기과
최우석 ( Choi Woo-Suk )
서울대학교 의과대학 비뇨기과학교실
유지형 ( Yu Ji-Hyeong )
분당서울대학교병원 비뇨기과
한준현 ( Han Jun-Hyun )
분당서울대학교병원 비뇨기과
장인호 ( Chang In-Ho )
분당서울대학교병원 비뇨기과
정성진 ( Jeong Seong-Jin )
분당서울대학교병원 비뇨기과
홍성규 ( Hong Sung-Kyu )
분당서울대학교병원 비뇨기과
변석수 ( Byun Seok-Soo )
분당서울대학교병원 비뇨기과
이상은 ( Lee Sang-Eun )
분당서울대학교병원 비뇨기과
KMID : 0358320070480060585
Abstract
Purpose: Metabolic syndrome, a concurrence of disturbed glucose and insulin metabolism, overweight, abdominal fat distribution, dyslipidemia, and hypertension, has been reported to have some association with prostate cancer. Here, we assessed the relationship between metabolic syndrome and prostate cancer.
Materials and Methods: We assessed a total of 261 men who underwent radical retropubic prostatectomy between January 2004 and May 2005. The patients were stratified into two groups, with metabolic syndrome(n=75) or without(n=186). Metabolic syndrome was defined by the criteria of National Cholesterol Education Program Adult Treatment Panel III. We compared the clinical and pathologic features of specimens between the groups.
Results: There was no significant difference between the two groups in terms of mean age, serum prostate specific antigen level, prostate size, Gleason score, and pathologic stage. The tumor volume of prostate cancer was significantly higher in the metabolic syndrome group(6.6?5.5cc vs 5.0?4.5cc, p=0.010). No significant differences were observed in extracapsular extension, seminal vesicle invasion, bladder neck invasion, angiolymphatic invasion, perineural invasion, and multicentricity of cancer between the two groups. As the component of metabolic syndrome increased, the tumor volume was also found to increase(p-value=0.025).
Conclusions: The data from our study support that metabolic syndrome is closely associated with the development and progression of prostate cancer.(Korean J Urol 2007;48:585-591)
키워드
Prostate neoplasm;Metabolic syndrome X
원문 및 링크아웃 정보
등재저널 정보