산수유 복합 추출 분말이 발기 부전증 환자에 미치는 임상적 효과와 안전성
Efficacy and Safety of a Herbal Formula that Mainly Consists of Cornus Officinalis for Erectile Dysfunction: A Double-blind, Placebo-controlled Study
감성철, 최세민, 제성욱, 이승현, 화정석, 정기현, 강창완, 현재석,
소속 상세정보
감성철 ( Kam Sung-Chul )
경상대학교 의과대학 비뇨기과학교실
최세민 ( Choi See-Min )
경상대학교 의과대학 비뇨기과학교실
제성욱 ( Jeh Sung-Uk )
경상대학교 의과대학 비뇨기과학교실
이승현 ( Lee Seung-Hyun )
경상대학교 의과대학 비뇨기과학교실
화정석 ( Hwa Jeong-Seok )
경상대학교 의과대학 비뇨기과학교실
정기현 ( Chung Ky-Hyun )
경상대학교 의과대학 비뇨기과학교실
강창완 ( Kang Chang-Wan )
동의대학교 데이터정보학교실
현재석 ( Hyun Jae-Seog )
경상대학교 의과대학 비뇨기과학교실
KMID : 0358320070480070741
Abstract
Purpose: The aim of this study was to evaluate the efficacy and safety of a herbal formula that mainly consists of Cornus officinalis for treating erectile dysfunction.
Materials & Methods: Eighty patients suffering with erectile dysfunction were enrolled in this randomized, double-blinded, placebo-controlled study. The average duration of erectile dysfunction of the herbal formula group(n=40) vs. the placebo group(n=40) were 19.33±18.13 months vs. 19.33±25.62 months, respectively. The safety variables we examined were the history, physical examination, vital signs, EKG, clinical laboratory tests and hormonal tests. Efficacy assessments included the International Index of Erectile Function(IIEF), the sexual encounter profile(SEP) diary and Global Assessment Questions(GAQ).
Results: No significant changes in the laboratory values, hormone tests and blood pressure were observed in both groups. In comparison with the placebo group(6.57±11.72), the herbal formula group experienced a significant improvement of the IIEF(11.13±11.83)(p＜0.05). When the herbal formula and placebo groups were divided by age and the IIEF score (age: 50 years and IIEF: 42) and then compared, the low IIEF group(IIEF≤42) and old age group(age≥50) of the herbal formula group significantly improved their IIEF score(p＜0.05). The herbal formula group significantly improved their GAQ score(p＜0.05). The herbal formula was well tolerated. The common adverse events were headache(2.5%) and nausea(5%).
Conclusion: In conclusion, the herbal formula that mainly consists Cornus officinalis was not only effective at improving erectile function, but it was also safe for the treatment of erectile dysfunction. (Korean J Urol 2007;48: 741-747)
키워드
Herbal formula;Erectile dysfunction;Treatment efficacy;Safety
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