Chronic Prostatitis/Chronic Pelvic Pain Syndrome을 가진 청장년 환자들에 대한 알푸조신의 치료효과
The Efficacy of Alfuzosin for Chronic Prostatitis/ Chronic Pelvic Pain Syndrome in Young and Middle Aged Patients
유영근, 김형지, 박흥재,
소속 상세정보
유영근 ( Ryu Young-Geun )
단국대학교 의과대학 비뇨기과학교실
김형지 ( Kim Hyung-Jee )
단국대학교 의과대학 비뇨기과학교실
박흥재 ( Park Heung-Jae )
성균관대학교 의과대학 비뇨기과학교실
KMID : 0358320070480080858
Abstract
Purpose: Many studies about efficacy of alpha blocker to Chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS) have shown variable results. The aim of this study was to confirm the efficacy of alpha blocker in young and middle aged patients with CP/CPPS to exclude the effect of benign prostatic hyperplasia.
Materials and Methods: Fifty seven men with CP/CPPS were randomized in a single-blind fashion, to receive either; tosufloxacin(450mg/d)(group 1; 15 patients), or; tosufloxacin(450mg/d) and alfuzosin(10mg/d)(group 2; 42 patients) for 2 months. The NIH chronic prostatitis symptom index (NIH-CPSI), International Prostate Symptom Score(IPSS) and International Index of Erectile Function-5(IIEF-5) were used to grade the symptoms and the quality of life(QoL) impact at the start and 1 and 2 months into the study.
Results: There was no significant difference between group 1 and group 2 in relation to age, duration and sub-factor scores of IPSS, NIH-CPSI and IIEF-5 at the baseline. No statistically significant difference in the NIH- CPSI total score was seen, but the urinary and QoL factors in group 2 showed greater improvement. A statistically significant difference was seen in the IPSS total score, especially, obstructive factor in group 2 showed greater improvement. The IIEF-5 total score was seen more increase, but it wasn’t significant.
Conclusions: The efficacy of alfuzosin demonstrated improvements in the NIH-CPSI(this was not significant.) and IPSS total score. Especially voiding factors were significantly improved in relation to the NIH-CPSI and IPSS scores in the alfuzosin treatment group.
키워드
Prostate; Alpha blocker; Pain
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