표재성 방광암의 재발 및 진행의 예측에 있어서 혈청 Creatinine 증가의 예후적 의의
The Prognostic Significance of Elevated Serum Creatinine for the Recurrence and Progression in Superficial Bladder Tumors
주재상, 최찬, 정승일, 박광성, 강택원, 권동득, 류수방, 김준석,
소속 상세정보
주재상 ( Joo Jae-Sang )
전남대학교 의과대학 비뇨기과학교실
최찬 ( Choi Chan )
전남대학교 의과대학 병리학교실
정승일 ( Jung Seung-Il )
전남대학교 의과대학 비뇨기과학교실
박광성 ( Park Kwang-Sung )
전남대학교 의과대학 비뇨기과학교실
강택원 ( Kang Taek-Won )
전남대학교 의과대학 비뇨기과학교실
권동득 ( Kwon Dong-Deuk )
전남대학교 의과대학 비뇨기과학교실
류수방 ( Ryu Soo-Bang )
전남대학교 의과대학 비뇨기과학교실
김준석 ( Kim Jun-Seok )
전남대학교 의과대학 비뇨기과학교실
KMID : 0358320070480090927
Abstract
Purpose:There are many prognostic indicators of bladder tumors including clinical, pathological and molecular markers based on tumor-related factors. This study was performed to evaluate the significance of an elevated level of serum creatinine for predicting progression and recurrence of superficial bladder tumors.
Materials and Methods:One hundred forty-seven patients that initially presented with a superficial bladder tumor(pTa or pT1) except for a carcinoma in situ were retrospectively analyzed according to several factors such as tumor stage, grade, size, multiplicity and serum creatinine for tumor recurrence and progression after a primary transurethral resection.
Results:The elevated serum creatinine group consisted of 20 patients 11 patients experienced recurrence(55.0%) and 3 patients experienced progression(15.0%). The control group consisted of 127 patients 39 patients experienced recurrence(30.7%) and 13 patients experienced progression (10.2%). The presence of an elevated level of serum creatinine and tumor multiplicity were statistically significant prognostic factors for tumor recurrence.
Conclusions:These results can be helpful for predicting the prognosis of transitional cell carcinoma of the bladder and for planning therapeutic and follow-up strategies. (Korean J Urol 2007;48:927-932)
키워드
Urinary bladder neoplasms;Prognosis;Creatinine
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