국소 신세포암으로 근치적 신적출술을 시행 받은 환자에서 술전 증상의 예후적 중요도
Prognostic Significance of the Pre-operative Symptoms in Patients after Radical Nephrectomy for Treating Localized Renal Cell Carcinoma
이승환, 오철영, 한웅규, 양승철,
소속 상세정보
이승환 ( Lee Seung-Hwan )
연세대학교 의과대학 비뇨기과학교실
오철영 ( Oh Cheol-Young )
연세대학교 의과대학 비뇨기과학교실, 비뇨의과학연구소
한웅규 ( Han Woong-Kyu )
연세대학교 의과대학 비뇨기과학교실
양승철 ( Yang Seung-Choul )
연세대학교 의과대학 비뇨기과학교실
KMID : 0358320070480121209
Abstract
Purpose : We investigated the relationship of the pre-operative symptoms to the other clinicopathologic factors that are known to be significant prognostic indicators for patients with renal cell carcinoma.
Material and Methods : Of the 398 patients who underwent an operation for renal cell carcinoma between March 1998 and May 2004, we retrospectively reviewed the clinical records of the 293 who were diagnosed and operated on for localized renal cell carcinoma. The patients were divided into three groups according to their pre-operative clinical symptoms. We then evaluated the patients’ characteristics, the pathological factors such as the cell type, tumor size, nuclear grade, the pathological T stage, tumor necrosis, the presence of a sarcomatoid component and multifocality by using ANOVA analysis. The overall survival was estimated using the Kaplan-Meier method and the log-rank test.
Results : Of the 293 cases, 118(40.3%) were in the symptomatic group and 175(59.7%) were in the asymptomatic groups. There was significant difference in the age, tumor size, the pathological T stage and tumor necrosis between the groups. There was a significant difference in the survival rates between the groups(p＜0.001).
Conclusion : Preoperative symptoms are important prognostic factors for patients with localized renal cell carcinoma. Therefore, determining the more specified symptoms is required for separating the groups with different survival after radical nephrectomy. (Korean J Urol 2007;48:1209- 1212)
키워드
Symptoms;Prognosis;Renal cell carcinoma
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