전립선비대증 환자에 대한 Tamsulosin 0.2mg 치료가 발기기능과 사정기능에 미치는 영향
Influence of 0.2mg Tamsulosin Treatment on the Erectile and Ejaculatory Functions in Patients with Benign Prostatic Hyperplasia
송상훈, 백재승, 손환철,
소속 상세정보
송상훈 ( Song Sang-Hoon )
서울대학교 의과대학 비뇨기과학교실
백재승 ( Paick Jae-Seung )
서울대학교 의과대학 비뇨기과학교실
손환철 ( Son Hwan-Cheol )
서울시립보라매병원 비뇨기과
KMID : 0358320070480121251
Abstract
Purpose : The aim of this study was to evaluate the influence of 8 weeks of 0.2mg tamsulosin medication on the erectile and ejaculatory functions of patients with benign prostatic hyperplasia(BPH).
Materials and Methods : 108 patients with BPH and they were without prostate cancer and neurogenic bladder were included in this study. Initial evaluations included a thorough history, digital rectal exam, urinalysis, serum prostate-specific antigen, uroflowmetry(UFM), post void residual urine measurement, transrectal ultrasound, International Prostatic Symptom Score(IPSS) and an International Index of Erectile Function(IIEF) and ejaculatory function questionnaire. After 4 and 8 weeks of medication, we analyzed the differences of these parameters at each week.
Results : The mean age of the patients was 61.3±9.0 years old and their prostate volume was 35.7±21.3ml. The IIEF erectile function(EF) domain score showed no statistically significant difference after medication. However, the orgasmic function domain score showed a significant decrease from 16.3±9.3 to 15.7±9.6 at the 4th and 8th week. Regarding the ejaculatory function, when the patients were divided into two groups according to the EF domain score(＜10, ≥11), the score of the ejaculatory volume showed a tendency to decrease from 2.5±1.0 to 2.2±1.2(p=0.07), and the score for satisfaction about ejaculation was decreased from 3.0±1.2 to 2.5±1.5(p=0.01) in the larger EF domain group after 8 weeks of treatment. The IPSS score and UFM parameters improved significantly after medication(p＜0.05).
Conclusion : For the patients with BPH, 8 weeks of 0.2mg tamsulosin medication caused significant improvement in their voiding function. In addition, our findings suggest that 0.2mg tamsulosin medication may the influence erectile and ejaculatory function. (Korean J Urol 2007;48:1251- 1257)
키워드
Tamsulosin;Benign prostatic hyperplasia;Erectile function;Ejaculation
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