흰쥐에서 신장 부분 절제 후 Oxidized Regenerated Cellulose 및 돼지 Small Intestine Submucosa를 삽입 후 생체 적합성 비교
Comparison of the Intraparenchymal Biocompatibility of Oxidized Regenerated Cellulose and Porcine Small Intestine Submucosa in Rat Kidney
한웅규, 김세훈, 양승철, 박종필,
소속 상세정보
한웅규 ( Han Woong-Kyu )
연세대학교 의과대학 비뇨기과학교실
김세훈 ( Kim Se-Hoon )
연세대학교 의과대학 병리학교실
양승철 ( Yang Seung-Choul )
연세대학교 의과대학 비뇨기과학교실
박종필 ( Park Jong-Pil )
연세대학교 의과대학 병리학교실
KMID : 0358320080490010043
Abstract
Purpose: The objective of this study was to evaluate the biological properties of a variety of materials that could be used in partial nephrectomy.
Materials and Methods: 54 Sprague-Dawley rats(9 for each group) divided into an experimental period of 4 and 12 weeks, respectively. 2 other groups were the negative control for this experiment. We inserted oxidized regenerated cellulose and porcine small intestine submucosa into the defected renal parenchyme in the experimental groups. At the end of the observation periods, the animals were killed and their specimens prepared for histological examination to evaluate the different materials biocompatibility.
Results: The reaction of the tissue to the materials diminished with time. After analyzing both periods, the inflammatory reactions to oxidized regenerated cellulose and porcine small intestine submucosa were considered slight. There were no significant differences between oxidized regenerated cellulose and porcine small intestine submucosa. Oxidized regenerated cellulose and porcine small intestine submucosa showed biocompatibility in this test model at both time periods.
Conclusions: It was concluded that there was no difference of biocompatibility between oxidized regenerated cellulose and porcine small intestine submucosa. Both materials are safe, biocompatible materials that can be inserted into the renal parenchyma.
키워드
Biocompatibility;Kidney;Rats
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