염증성 만성골반통증후군 환자에서 항생제 단독요법과 항생제 및 알파차단제 병합요법의 치료효과 비교
Comparison of the Efficacy of Antibiotic Monotherapy and Antibiotic Plus Alpha-blocker Combination Therapy for Patients with Inflammatory Chronic Prostatitis/Chronic Pelvic Pain Syndrome
윤철웅, 박광성, 권동득, 류수방, 손경철, 최향식,
소속 상세정보
윤철웅 ( Youn Chul-Woong )
전남대학교 의과대학 비뇨기과학교실
박광성 ( Park Kwang-Sung )
전남대학교 의과대학 비뇨기과학교실
권동득 ( Kwon Dong-Deuk )
전남대학교 의과대학 비뇨기과학교실
류수방 ( Ryu Soo-Bang )
전남대학교 의과대학 비뇨기과학교실
손경철 ( Son Kyung-Chul )
전남대학교 의과대학 비뇨기과학교실
최향식 ( Choi Hyang-Sik )
전남대학교 의과대학 비뇨기과학교실
KMID : 0358320080490010072
Abstract
Purpose: The objectives of this study was to compare the efficacy of antibiotic monotherapy with antibiotic plus alpha-blocker combination therapy for the treatment of inflammatory chronic pelvic pain syndrome (CPPS) patients.
Materials and Methods: Between October 2005 and May 2006, 69 patients who were diagnosed as CPPS(National Institutes of Health; NIH-catagory IIIa), were included in this study. The patients were randomly placed into two groups: group I was treated with gatifloxacin alone(35 patients), and group II was treated with gatifloxacin and doxazosin(34 patients) for 6 weeks. For all the patients, the urinalysis, expressed prostatic massage, the National Institute of Health-Chronic Prostatitis Symptom Index(NIH- CPSI) and a distal rectal examination(DRE) were performed at the initial visit. The NIH-CPSI was compared both before and after the treatment.
Results: On the initial diagnosis, the mean CPSI of the group I patients was 24.0±6.3, and that for the group II patients was 24.7±6.9. After the treatment, that of the group I was 16.6±5.4, and that of group II was 13.4±5.3. After 6 weeks of treatment, the changes in the total CPSI scores had significantly improved in group II compared with group I(p＜0.05). A statistically significant improvement occurred in the pain score, the voiding symptom score and the quality of life in the group II compared with group I(p＜0.05)
Conclusions: This study suggests that combination therapy of antibiotic plus alpha-blocker would be more effective than antibiotic monotheraphy for treating patients with inflammatory chronic prostatitis/chronic pelvic pain syndrome.
키워드
Prostatitis;Pelvic pain;Adrenergic alpha-blockers;Antibiotics
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