투명 신세포암의 예후인자로서의 Caveolin-1과 Ki-67의 면역조직화학적 발현
Caveolin-1 and Ki-67 Expression as Prognostic Factors in Clear Cell Carcinoma of the Kidney
김병훈, 김천일, 박철희,
소속 상세정보
김병훈 ( Kim Byung-Hoon )
대구광역시 달성군 보건소
김천일 ( Kim Chun-Il )
계명대학교 의과대학 비뇨기과학교실
박철희 ( Park Choal-Hee )
계명대학교 의과대학 비뇨기과학교실
KMID : 0358320080490020099
Abstract
Purpose: Caveolin-1 is proposed to represent a novel tumor suppressor protein and expression of recombinant caveolin-1 is sufficient to restrict the growth potential of transformed cells isolated from primary tumors of the breast, lung, and ovaries. We examined the relationship of caveolin-1 and Ki-67 expression to clinicopathological variables in patients with clear cell carcinomas of the kidney.
Materials and Methods: We examined caveolin-1 and Ki-67 expression in 119 clear cell carcinomas of the kidney using immunohistochemistry, and analyzed its relationship with tumor size, nuclear grade, TNM stage, vascular invasion, capsular invasion, metastasis, and metachronous metastasis were investigated.
Results: Of the 119 tumors analyzed, lymph node and distant metastasis (synchronous metastasis: 7, metachronous metastasis: 15) occurred in 3 and 22 cases, respectively. Caveolin-1 expression correlated with the T stage(p=0.004), TNM stage(p=0.013), metastasis(p=0.013), and metachronous metastasis(p=0.001). Ki-67 expression correlated with the T stage(p=0.041), nuclear grade(p=0.011), and vascular invasion(p=0.043). Caveolin-1 and Ki-67 expression showed similar changes, but there was no statistical significance(p=0.050).
Conclusions: Caveolin-1 is expressed frequently in patients with metachronous metastasis, and may predict metastasis after surgery for clear cell carcinoma of the kidney. (Korean J Urol 2008;49:99-106)
키워드
Clear cell renal carcinoma;Caveolin 1;Ki-67 antigen
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