이미프라민과 데스모프레신이 야뇨증 환자에서 수면 중 각성에 미치는 영향에 대한 다기관연구
A Multicenter Prospective Study of the Effect of Imipramine and Desmopressin on Arousability in Children with Nocturnal Enuresis
김준모, 김영식, 남궁미경, 박관현, 박용훈, 이상돈, 이승주, 정재용,
소속 상세정보
김준모 ( Kim Jun-Mo )
순천향대학교 의과대학 비뇨기과학교실
김영식 ( Kim Young-Sig )
일산병원 비뇨기과
남궁미경 ( Namgoong Mee-Kyung )
연세대학교 원주의과대학 소아청소년과학교실
박관현 ( Park Kwan-Hyun )
성균관대학교 의과대학 비뇨기과학교실
박용훈 ( Park Yong-Hoon )
영남대학교 의과대학 소아과학교실
이상돈 ( Lee Sang-Don )
부산대학교 의과대학 비뇨기과학교실
이승주 ( Lee Seung-Joo )
이화여자대학교 의과대학 소아과학교실
정재용 ( Chung Jae-Yong )
인제대학교 의과대학 비뇨기과학교실
KMID : 0358320080490020168
Abstract
Purpose: We performed a multicenter, prospective study to evaluate the efficacy of imipramine and desmopressin to improve arousability and prevent nocturnal enuresis(NE).
Materials and Methods: The total of 48 children with NE were given questionnaires that included a scoring system for the assessing arousal from sleep. They were assigned into two groups: group 1(imipramine 25 mg, 3 girls and 16 boys, mean age 7.9 years), group 2(desmopressin 0.2 mg, 9 girls and 9 boys, mean age 7.5 years). The assessment of arousability was repeated 2 weeks and 4 weeks after medication. Eleven children were excluded because of incomplete data.
Results: Mean wetting events in group 1 decreased from 8.8 to 5.1 times(2 weeks) and 3.0 times(4 weeks)(p=0.009) versus 10.2 to 5.5 times(2 weeks) and 6.4 times(4 weeks)(p=0.007) for group 2. The mean threshold of arousability in group 1 was 4.9(baseline), 4.4(2 weeks), and 3.7(4 weeks), and, for group 2, 5.1(baseline), 4.8(2 weeks), and 4.8(4 weeks). The two groups were not different(p=0.14, p=0.73).
Conclusions: Imipramine and desmopressin, which are commonly used in treating NE in Korea, influenced wetting events but not arousability. (Korean J Urol 2008;49:168-173)
키워드
Nocturnal enuresis;Arousal;Imipramine;Deamino arginine vasopressin
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