전립선비대증 환자에서 5알파환원효소 억제제 투여가 Survivin과 Bcl-2의 발현에 미치는 영향
Expression of Survivin and Bcl-2 in Benign Prostatic Hyperplasia Treated with a 5-alpha-reductase Inhibitor
차우헌, 장석용, 이경섭,
소속 상세정보
차우헌 ( Cha Woo-Heon )
동국대학교 의과대학 비뇨기과학교실
장석용 ( Jang Suk-Yong )
동국대학교 의과대학 병리학교실
이경섭 ( Lee Kyung-Seop )
동국대학교 의과대학 비뇨기과학교실
KMID : 0358320080490030242
Abstract
Purpose: A 5-alpha-reductase inhibitor(5?RI) can induce apoptosis and decrease the prostatic volume in patients with benign prostatic hyperplasia (BPH). In this study we assessed the expression of survivin and bcl-2 in the epithelium of BPH patients treated with finasteride.
Materials and Methods: Group 1 consisted of 39 patients who underwent transurethral resection of the prostate(TURP) without medication and Group 2 consisted of 31 patients who underwent TURP and were treated with finasteride for more than three months. The mean age of both groups of patients was 73.03±7.02 years and 74.71±5.99 years, respectively. Immunohistochemical staining for survivin, bcl-2 and ki-67 was performed in prostatic tissues. The percentage of cells that expressed survivin and bcl-2 were classified into four categories based on the staining intensity. The expression of ki-67 in nuclei using 10 random cells per specimen was obtained. The relationship between 5?RI and the expression of survivin, bcl-2 and ki-67 was analyzed.
Results: The total mean prostate volume of group 1 patients and group 2 patients was 45.51ml and 37.23ml, respectively (p＜0.001) and the mean serum total prostate specific antigen(PSA) level of group 1 patients and group 2 patients was 5.09ng/ml and 3.75ng/ml, respectively(p=0.105). Decreased expression of survivin and bcl-2 in specimens from group 2 patients was observed as compared to the level of expression in group 1 patients(p＜0.001, p=0.001). Expression of ki-67 determined in samples from both groups was not significantly different(p=0.345).
Conclusions: We suggest that finasteride may induce apoptosis of prostatic epithelial cells in BPH patients by reducing the expression of survivin and bcl-2. These findings may indicate a reduction of prostatic volume. (Korean J Urol 2008;49:242-247)
키워드
Prostatic hyperplasia;Apoptosis;Survivin;Bcl-2
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