인체 방광암에서 Peroxiredoxin I의 발현에 관한 분석
Analysis of the Expression of Peroxiredoxin I in Human Bladder Cancer
김은탁, 사공혁, 김원재,
소속 상세정보
김은탁 ( Kim Eun-Tak )
을지대학교 의과대학 비뇨기과학교실
사공혁 ( Sa Gong-Hyuk )
을지대학교 의과대학 비뇨기과학교실
김원재 ( Kim Wun-Jae )
Chungbuk National University
KMID : 0358320080490040300
Abstract
Purpose : Peroxiredoxins(PRDXs) are antioxidant enzymes that play an important role on cell differentiation, proliferation and apoptosis. In this study, we investigated if the expression levels of PRDX I were related to bladder cancer.
Materials & Methods : The mRNA level of PRDX I was examined via real time polymerase chain reaction(PCR) in 186 cancer specimens from patients with primary bladder cancer, 73 corresponding samples of normal looking bladder mucosae surrounding the cancer and 21 samples of normal bladder mucosae. We investigated the correlation between the expression levels of PRDX I and the clinico-pathological parameters of the 154 patients who could be followed up more than three years.
Results : The expression levels of PRDX I in bladder cancer(0.73pg/ml) were significantly higher that that in the normal bladder mucosae (0.04 pg/ml)(p＜0.01) or that in the corresponding normal bladder mucosae surrounding the cancer(0.38pg/ml)(p＜0.01). The expression level of PRDX I was not significantly enhanced in the non-recurred(0.87pg/ml) superficial bladder tumor patients compared with the recurred superficial bladder tumor patients(0.63pg/ml), but it was significantly enhanced in the non-progressed(0.82pg/ml) patients compared with the progressed (0.50pg/ml) patients(p＜0.05 for each).
Conclusion : An enhanced expression of PRDX I is strongly associated with the development of bladder cancer. Moreover, enhanced expressions of PRDX I are also positively associated with a low rate of progression of bladder cancer, and this might be useful as a marker for assessing progression in human bladder cancers. (Korean J Urol 2008;49:300-306)
키워드
Peroxiredoxin I; Bladder tumor
원문 및 링크아웃 정보
등재저널 정보